Can high-flow nasal cannula reduce the rate of reintubation in adult patients after extubation? A meta-analysis

BMC Pulmonary Medicine

Table 1 Details of the eight enrolled studies

Author(Year)	Study design	NCT No.	Country	Control	Population	Underlying disease	Outcome^a
Corley 2015	Randomised controlled trial	ACTRN12610000942055	Australia	Standard oxygen therapy	155	Cardiac surgery	②③
Fernández 2017	Randomised controlled trial	NCT01820507	Spain	COT	155	Chronic obstructive pulmonary disease, heart failure	①②③
Futier 2016	Multicenter randomized trial	NCT01887015	France	Standard oxygen therapy	220	Major abdominal surgery	①②③④
Hernández 2016	Multicenter randomized trial	NCT01191489	Spain	COT	527	Medical,trauma,surgical	①②③④⑤
Hernández 2016 (2)	Multicenter randomized trial	NCT01191489	Spain	NIPPV	604	Medical,trauma,surgical	①②③④⑤
Maggiore 2014	Randomized controlled open-label trial	NCT01575353	Italian	Venturi mask	105	Pneumonia, multiple trauma, atelectasis, shock, cardiogenic pulmonary edema, cardiac arrest, other	①②③⑤
Parke 2013	Pragmatic randomized controlled trial	ACTRN12610000973011	New Zealand	Simple facemask or nasal prongs	340	Cardiac surgery	②③⑥
Stéphan 2016	Multicente,r randomised,noinferiorty trail	NCT01458444	France	NIPPV	830	Cardiothoracic surgery	①②③④⑤⑥⑦

^aOutcome measures include:①mortality;②rate of endotracheal intubation; ③length of ICU stay;④adverse events;⑤respiratory variables;⑥patient comfort;⑦dyspnea scale
AECOPD acute exacerbation of chronic obstructive pulmonary disease; ARDS acute respiratory distress syndrom; ARF acute respiratory failure; COPD chronic obstructive pulmonary disease;COT conventional oxygen therapy; HFNC high flow nasal cannula; NIPPV noninvasive positive pressure ventilation; NR not report; SIRS systemic inflammatory response syndrome

ISSN: 1471-2466