Variablesa | Low DSSb (n = 42) | High DSS (n = 23) | P value |
---|---|---|---|
Age (median years [IQR]) | 48 (41–59) | 46 (44–59) | 0.878 |
Male | 24 (57.1) | 16 (69.6) | 0.325 |
Smoking status (n = 61) |  |  | 0.023 |
 Never smoker | 18 (46.2) | 9 (40.9) | 0.692 |
 Ex-smoker | 14 (35.9) | 2 (9.1) | 0.018 |
 Current smoker | 7 (17.9) | 11 (50.0) | 0.008 |
Presence of symptoms | 33 (78.6) | 22 (95.7) | 0.084 |
 Presence of dyspnea | 25 (59.5) | 19 (82.6) | 0.057 |
Presence of dust exposure (n = 59) | 18 (47.4) | 11 (52.4) | 0.712 |
Type of exposed dust | |||
 Farming | 0 (0) | 5 (45.4) | 0.004 |
 Metal | 6 (33.3) | 3 (27.3) | 1.000 |
 Stone or sand | 4 (22.2) | 0 (0) | 0.268 |
 Chemical or paint | 4 (22.2) | 1 (9.1) | 0.622 |
 Diesel | 2 (11.1) | 2 (18.2) | 0.622 |
 Textile | 1 (5.6) | 0 (0) | 1.000 |
 Wood | 1 (5.6) | 0 (0) | 1.000 |
FVC % predicted | 83.2 ± 15.5 | 73.3 ± 16.1 | 0.05 |
DLCO % predicted | 75.6 ± 23.9 | 51.0 ± 22.8 | 0.001 |
PaO2 mm Hg | 88.8 ± 25.2 | 61.4 ± 9.5 | <0.001 |
D(A-a)O2 mm Hg | 20.7 ± 11.1 | 42.2 ± 11.7 | <0.001 |
LDH U/L | 433.9 ± 182.4 | 352.6 ± 157.3 | 0.251 |
CEA ng/mL | 6.4 ± 8.7 | 9.6 ± 8.6 | 0.294 |
Treatment | Â | Â | 0.116 |
 No | 21 (50.0) | 7 (30.4) | 0.128 |
 Whole lung lavage | 18 (42.9) | 16 (69.6) | 0.039 |
 Segmental lavage | 2 (4.8) | 0 (0) | 0.536 |
 GM-CSFc | 3 (7.1) | 0 (0) | 0.547 |