Effect of sivelestat sodium in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of randomized controlled trials

Table 1 Baseline characteristic of studies included in the systematic review and meta-analysis

Study	Publication year	Country	Sample size	Mean age	Percentage male (%)	Disease status	Intervention	Baseline PaO₂/FiO₂ ratio	Baseline APACHE II score	Jadad scale
Endo [22]	2006	Japan	26	NA	NA	ALI	0.2 mg/kg/h for 14 days	NA	NA	3
Sato [23]	2008	Japan	24	69.0	75.0	ALI/ARDS	0.2 mg/kg/h for 14 days	196.5	NA	2
Morimoto [24]	2011	Japan	22	73.1	63.6	ALI	0.2 mg/kg/h huntil weaning from mechanical ventilation	<150.0	NA	3
Kadoi [25]	2004	Japan	24	64.0	75.0	ARDS	0.2 mg/kg/h for 14 days	148.5	20.1	2
Zeiher [26]	2004	Multiple countries	487	56.0	59.3	ALI	0.16 mg/kg/h for 14 days	148.7	20.8	3
Tamakuma [27]	2004	Japan	221	57.8	76.0	ALI	0.2 mg/kg/h for 14 days	199.0	NA	3

ALI Acute lung injury, APACHE II acute physiology and chronic health evaluation, ARDS acute respiratory distress syndrome, FiO ₂ fractional inspired oxygen, PaO ₂ arterial oxygen partial pressure

ISSN: 1471-2466