Table 2 Summary of Aspergillus-specific antibody titers and total serum IgE in HIV/TB patients in relation to selected baseline characteristics
Test/ Assay/ Cut-off | Factor at TB diagnosis | BASELINE | WEEK 24 | Overall P value$ | ||||
|---|---|---|---|---|---|---|---|---|
N | Median (IQR) | P value* | N | Median (IQR) | P value* | |||
Aspergillus IgG ImmunoCAP® cut-off = 40 mg/L | Overall | 76 | 4.4 (2.1,7.2) | NA | 94 | 4.9 (2.1, 9.1) | NA | 0.02 |
Not on ART | 52 | 4.3 (2.1,7.3) | 0.85 | 65 | 4.9 (2.7,10.4) | 0.35 | ||
On ART | 24 | 4.8 (2.0,6.9) | 28 | 2.8 (2.0,7.5) | ||||
CD4 < 100/μL | 26 | 6.2 (2.7,8.7) | 0.01 | 31 | 5.3 (2.1,12.7) | 0.47 | ||
CD4 ≥ 100/μL | 47 | 3.2 (2.0,6.0) | 59 | 4.8 (2.1,7.5) | ||||
Coughed for <3 weeks | 27 | 5.2 (2.1,8.5) | 0.50 | 29 | 4.9 (2.3,10.4) | 0.96 | ||
Coughed for ≥3 weeks | 49 | 4.3 (2.0,7.1) | 64 | 4.9 (2.1,9.0) | ||||
No Chest pain | 41 | 5.4 (2.7,8.2) | 0.03 | 55 | 4.8 (2.1,8.8) | 0.95 | ||
Chest pain | 35 | 2.9 (2.0,6.2) | 38 | 5.1 (2.4,10.1) | ||||
Abnormal Chest X-Ray | 59 | 4.3 (2.0,7.1) | 0.79 | 75 | 4.9 (2.1,8.8) | 0.88 | ||
Normal Chest X-Ray | 6 | 3.9 (2.6,8.7) | 6 | 3.1 (2.1,10.9) | ||||
Aspergillus IgG Immulite® cut-off = 20 mg/L | Overall | 75 | 7.5 (6.1, 10.3) | NA | 87 | 7.2 (6.1, 9.96) | NA | 0.66 |
Not on ART | 52 | 8.0 (6.7,10.6) | 0.03 | 61 | 7.6 (6.2,10.5) | 0.27 | ||
On ART | 23 | 6.6 (5.8,8.2) | 26 | 6.9 (6.1,8.8) | ||||
CD4 < 100/μL | 25 | 7.9 (5.9,9.1) | 0.94 | 29 | 7.8 (6.0,11.3) | 0.60 | ||
CD4 ≥ 100/μL | 47 | 7.5 (6.1,10.4) | 56 | 7.0 (6.1,9.5) | ||||
Coughed for <3 weeks | 26 | 7.3 (6.0,8.8) | 0.37 | 28 | 7.6 (5.9,10.5) | 0.98 | ||
Coughed for ≥3 weeks | 49 | 7.5 (6.4,10.7) | 59 | 7.2 (6.2,8.8) | ||||
No Chest pain | 40 | 7.5 (6.4,10.8) | 0.54 | 51 | 7.5 (6.1,9.7) | 0.92 | ||
Chest pain | 35 | 7.9 (6.0,9,3) | 36 | 7.2 (6.1,10.8) | ||||
Abnormal Chest X-Ray | 58 | 7.5 (6.1,9.1) | 0.30 | 69 | 7.0 (6.1,10.1) | 0.80 | ||
Normal Chest X-Ray | 6 | 6.8 (5.0,8.2) | 6 | 8.2 (7.5,8.7) | ||||
Total IgE Immulite® cut-off = 1000 IU/mL | Overall | 76 | 379 (129, 908) | NA | 85 | 251 (64, 794) | NA | <0.01 |
Not on ART | 52 | 371 (122,1059) | 0.82 | 59 | 297 (55,1021) | 0.53 | ||
On ART | 24 | 382 (175,837) | 26 | 231 (77,777) | ||||
CD4 < 100/μL | 26 | 462 (149,1440) | 0.11 | 29 | 595 (113,1272) | 0.03 | ||
CD4 ≥ 100/μL | 47 | 355 (114,634) | 54 | 185 (57,532) | ||||
Coughed for <3 weeks | 27 | 207 (48,489) | 0.02 | 26 | 213 (39,821) | 0.49 | ||
Coughed for ≥3 weeks | 49 | 493 (172,1200) | 59 | 359 (71,794) | ||||
No Chest pain | 41 | 355 (149,605) | 0.40 | 49 | 183 (55,570) | 0.06 | ||
Chest pain | 35 | 489 (121,1221) | 36 | 460 (72,1192) | ||||
Abnormal Chest X-Ray | 59 | 457 (149,1055) | 0.53 | 68 | 332 (66,835) | 0.54 | ||
Normal Chest X-Ray | 6 | 401 (322,1487) | 6 | 153 (73,292) | ||||
NORMAL (≤0.35), n(%) | HIGH (>0.35), n(%) | P-VALUE | ||||||
Aspergillus IgE ImmunoCAP® cut-off = 0.35 kU/L | Overall, N = 93 | NOT APPLICABLE | 84 (90.3) | 9 (9.7) | ||||
Not on ART | 59(90.8) | 6(9.2) | 0.99 | |||||
On ART | 25(89.3) | 3(10.7) | ||||||
CD4 < 100/μL | 26 (83.9) | 5 (16.1) | 0.26 | |||||
CD4 ≥ 100/μL | 56 (93.3) | 4 (6.7) | ||||||
Coughed for <3 weeks | 25(86.2) | 4(13.8) | 0.45 | |||||
Coughed for ≥3 weeks | 59(92.2) | 5(7.8) | ||||||
No Chest pain | 51(92.7) | 4(7.3) | 0.48 | |||||
Chest pain | 33(86.8) | 5(13.2) | ||||||
Abnormal Chest X-Ray | 67(89.3) | 8(10.7) | 0.99 | |||||
Normal Chest X-Ray | 6(100.0) | 0 (0.0) | ||||||