Different effects of cardiac and diaphragm function assessed by ultrasound on extubation outcomes in difficult-to-wean patients: a cohort study

Table 2 Laboratory and ultrasonic data before and after SBT

	Respiratory failure within 48 h
Variables	RF subgroup	ES subgroup
N (cases)	29	31
Before SBT
PH	7.45 ± 0.06	7.46 ± 0.05
PaCO₂ (mmHg)	46.4 ± 13	39.1 ± 5.1*
PaO₂/FiO₂	277 ± 83	281 ± 80
Lactic acid (mmol/l)	1.2 ± 0.6	1.1 ± 0.4
NT-pro-BNP(pg/ml)	6519 ± 9162	1578 ± 1843*
Pleural effusion	22 (76)	24 (77)
LVEF (%)	57 ± 14	64 ± 9*
E (cm/s)	92.9 ± 25.6	78.2 ± 18.4*
E/Ea (septal)	18.2 ± 8.1	13 ± 3.8*
E/Ea (lateral)	12.8 ± 5.1	8.4 ± 2.7^†
E/Ea (average)	14.7 ± 5.6	10.1 ± 2.8^†
DE (right) (mm)	11.2 ± 4.7	10.1 ± 4.7
DE (left) (mm)	11.6 ± 6.3	10.8 ± 5.5
DE (average) (mm)	11.4 ± 4.5	10.5 ± 3.4
After SBT
PH	7.43 ± 0.05	7.47 ± 0.05*
PaCO₂ (mmHg)	48 ± 11.7	38.7 ± 5.5^†
PaO₂/FiO₂	291 ± 103	275 ± 79
Lactic acid (mmol/l)	1.1 ± 0.5	1.1 ± 0.5
NT-pro-BNP(pg/ml)	6518 [421-10,477]	1471[176-1575]*
E (cm/s)	99.7 ± 24.3	85.1 ± 18.2*
E/Ea (septal)	18.6 ± 6.5	13.4 ± 4.4*
E/Ea (lateral)	14.4 ± 7.3	9.0 ± 3.0*
E/Ea (average)	15.8 ± 6.2	10.6 ± 3.2^†
DE (right) (mm)	13.7 ± 6	11 ± 4.4
DE (left) (mm)	13.8 ± 6.4	13 ± 5.4
DE (average) (mm)	13.7 ± 5.4	12 ± 3.4

Data are presented as median ± SD or median (IQR) or n (%). DE diaphragmatic excursion, E mitral Doppler early peak diastolic velocity, E/Ea the ratio of mitral Doppler inflow velocity to annular tissue Doppler wave velocity, ES extubation success, LVEF left ventricular ejection fraction, NT-pro-BNP N-terminal-pro-B-type natriuretic peptide, PaCO ₂ arterial carbon dioxide tension, PaO ₂ /FiO ₂ the ratio of arterial oxygen tension to fraction of inspired oxygen, RF respiratory failure, SBT spontaneous breathing trial. * Significant at p < 0.05, and ^† significant at p < 0.001

ISSN: 1471-2466