Table 2 Association between patients’ characteristics and biomarkers on baseline Forced Expiratory Volume in 1 Second (FEV1) assessed in millilitres (mL) and annual rate of change in FEV1. Data are shown as mean ± standard error (SE). Data are generated from a random-coefficient model. The p-values are not corrected for multiple testing
Marker | Associationa with baseline FEV1 | P value | Associationa with annual rate of change in FEV1 | P value |
|---|---|---|---|---|
mL | mL/yr | |||
Serological biomarkers | ||||
BL CC-16 | 38.1 ± 15.2 | 0.012 | −3.0 ± 4.0 | 0.50 |
BL SP-D | 7.6 ± 14.4 | 0.60 | −2.9 ± 3.8 | 0.50 |
BL WBC | −24.0 ± 14 | 0.09 | −2.8 ± 3.8 | 0.50 |
MO6 C1M | −45.2 ± 14.4 | 0.002 | 10.4 ± 3.9 | 0.007 |
MO6 C6M | −46.5 ± 14.2 | 0.0011 | 8.6 ± 3.8 | 0.03 |
Y1 hsCRP | −53.3 ± 14.7 | 0.0003 | 8.2 ± 4.0 | 0.04 |
Y1 Fibrinogen | −53.3 ± 14.3 | 0.0002 | 6.8 ± 3.9 | 0.08 |
Patients characteristics at baseline | ||||
Age (per yr) | −13.1 ± 2.1 | < 0.0001 | 0.9 ± 0.6 | 0.10 |
SEX (female vs male) | −358 ± 30.9 | < 0.0001 | 6.8 ± 8.2 | 0.41 |
BMI (kg/m2) | 10.7 ± 2.7 | < 0.0001 | 0.2 ± 0.7 | 0.79 |
# prior AECOPD | ||||
1 vs 0 | −172 ± 35.0 | < 0.0001 | 2.8 ± 9.6 | 0.77 |
2 vs 0 | −151 ± 42.8 | 0.0004 | 18.9 ± 11.8 | 0.11 |
≥ 3 vs 0 | −323 ± 42.2 | < 0.0001 | 13.9 ± 13.8 | 0.31 |
AECOPD FU | Na | Na | −1.8 ± 1.9 | 0.35 |
Current smoker (yes vs no) | −19.4 ± 32.1 | 0.55 | −30.7 ± 8.5 | 0.0003 |
Bronchodilator reversibility (yes vs. no) | 241 ± 34.3 | < 0.0001 | −22.8 ± 9.1 | 0.012 |
Significant emphysema (yes vs. no) | −347 ± 31.6 | < 0.0001 | −27.9 ± 8.4 | 0.001 |
Chronic bronchitis (yes vs no) | −35.4 ± 31.1 | 0.26 | −9.7 ± 8.2 | 0.24 |
#Pack years | −0.8 ± 0.6 | 0.17 | 0.1 ± 0.2 | 0.68 |