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Table 2 Association between patients’ characteristics and biomarkers on baseline Forced Expiratory Volume in 1 Second (FEV1) assessed in millilitres (mL) and annual rate of change in FEV1. Data are shown as mean ± standard error (SE). Data are generated from a random-coefficient model. The p-values are not corrected for multiple testing

From: Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

Marker Associationa with baseline FEV1 P value Associationa with annual rate of change in FEV1 P value
mL mL/yr
Serological biomarkers
 BL CC-16 38.1 ± 15.2 0.012 −3.0 ± 4.0 0.50
 BL SP-D 7.6 ± 14.4 0.60 −2.9 ± 3.8 0.50
 BL WBC −24.0 ± 14 0.09 −2.8 ± 3.8 0.50
 MO6 C1M −45.2 ± 14.4 0.002 10.4 ± 3.9 0.007
 MO6 C6M −46.5 ± 14.2 0.0011 8.6 ± 3.8 0.03
 Y1 hsCRP −53.3 ± 14.7 0.0003 8.2 ± 4.0 0.04
 Y1 Fibrinogen −53.3 ± 14.3 0.0002 6.8 ± 3.9 0.08
Patients characteristics at baseline
 Age (per yr) −13.1 ± 2.1 < 0.0001 0.9 ± 0.6 0.10
 SEX (female vs male) −358 ± 30.9 < 0.0001 6.8 ± 8.2 0.41
 BMI (kg/m2) 10.7 ± 2.7 < 0.0001 0.2 ± 0.7 0.79
# prior AECOPD
 1 vs 0 −172 ± 35.0 < 0.0001 2.8 ± 9.6 0.77
 2 vs 0 −151 ± 42.8 0.0004 18.9 ± 11.8 0.11
≥ 3 vs 0 −323 ± 42.2 < 0.0001 13.9 ± 13.8 0.31
AECOPD FU Na Na −1.8 ± 1.9 0.35
Current smoker (yes vs no) −19.4 ± 32.1 0.55 −30.7 ± 8.5 0.0003
Bronchodilator reversibility (yes vs. no) 241 ± 34.3 < 0.0001 −22.8 ± 9.1 0.012
Significant emphysema (yes vs. no) −347 ± 31.6 < 0.0001 −27.9 ± 8.4 0.001
Chronic bronchitis (yes vs no) −35.4 ± 31.1 0.26 −9.7 ± 8.2 0.24
#Pack years −0.8 ± 0.6 0.17 0.1 ± 0.2 0.68
  1. CC-16 Club-cell secretory protein-16, SP-D Surfactant protein-D, WBC white blood cell count, C1M MMP derived collagen type I fragment, C6M MMP derived collagen type VI fragment, hsCRP high sensitive C-reactive protein, BMI Body mass index, AECOPD Acute exacerbations in COPD, FU Follow up, aThe association are calculated as per increase in 1SD in each biomarker or as indicated for each patient characteristics. na: non applicable
  2. all p values below <0.05 should be bold and italic