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Table 3 Meta-analysis of CHI3L1 rs4950928 and CHIA rs10494132 polymorphisms and asthma

From: Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis

Subgroup

Genetic model

Genotype/Allele

Type of model

Heterogeneity

Test of Association

I2

P het

OR

95% CI

P meta

rs4950928

 Overall

Recessive model

GG vs. GC + CC

F

0.00%

0.430

0.946

0.626–1.428

0.791

Dominant model

GG + GC vs. CC

R

86.70%

0.000

0.917

0.767–1.097

0.342

Codominant model

GC vs. CC

R

85.80%

0.000

0.915

0.759–1.103

0.351

Homozygote model

GG vs. CC

F

39.10%

0.160

0.889

0.588–1.346

0.579

Allele model

G vs. C

R

84.90%

0.000

0.933

0.802–1.085

0.369

 Caucasians

Recessive model

GG vs. GC + CC

F

21.40%

0.128

0.794

0.475–1.327

0.378

Dominant model

GG + GC vs. CC

R

70.20%

0.035

0.621

0.484–0.797

0.000

Codominant model

GC vs. CC

R

65.70%

0.054

0.612

0.470–0.796

0.000

Homozygote model

GGvs. CC

F

40.40%

0.187

0.675

0.402–1.134

0.138

Allele model

G vs. C

R

68.70%

0.041

0.696

0.567–0.856

0.001

 Children

Recessive model

GG vs. GC + CC

F

28.00%

0.249

0.844

0.529-1.346

0.476

Dominant model

GG + GC vs. CC

R

91.90%

0.000

0.955

0.782–1.166

0.651

Codominant model

GC + CC

R

90.90%

0.000

0.970

0.788-1.196

0.777

Homozygote model

GG vs. CC

R

64.00%

0.062

0.797

0.499-1.275

0.345

Allele model

G vs. C

R

91.30%

0.000

0.946

0.799–1.120

0.522

rs10494132

 Overall

Recessive model

TT vs. TC + CC

F

35.80%

0.182

1.212

0.981–1.497

0.075

Dominant model

TT + TC vs. CC

F

21.80%

0.276

0.857

0.597–1.230

0.403

Codominant model

TC vs. CC

F

0.00%

0.455

0.748

0.504–1.109

0.149

Homozygote model

TT vs. CC

F

24.70%

0.257

0.916

0.630–1.331

0.646

Allele model

T vs. C

R

57.90%

0.050

1.094

0.924–1.297

0.298

 Asians

Recessive model

TT vs. TC + CC

F

29.80%

0.240

1.476

1.071–2.032

0.017

Dominant model

TT + TC vs. CC

F

48.10%

0.145

1.125

0.654–1.933

0.671

Codominant model

TC vs. CC

F

24.60%

0.266

0.926

0.507–1.691

0.802

Homozygote model

TT vs. CC

F

48.90%

0.141

1.249

0.709-2.199

0.441

 

Allele model

T vs. C

R

64.00%

0.062

1.326

1.024–1.717

0.032

 Children

Recessive model

TT vs. TC + CC

F

30.60%

0.263

1.472

1.067–2.030

0.019

Dominant model

TT + TC vs. CC

F

53.00%

0.119

1.101

0.629–1.927

0.737

Codominant model

TC vs. CC

F

34.70%

0.216

0.903

0.485–1.681

0.748

Homozygote model

TT vs. CC

F

53.30%

0.117

1.217

0.679–2.184

0.510

Allele model

T vs. C

R

64.90%

0.058

1.320

1.016–1.713

0.037

  1. OR Odds ratio, CI Confidence interval, P hetP-value of heterogeneity test, P meta P-value of pooled effect, R Random effect model, F Fixed effect model