Subgroup | Genetic model | Genotype/Allele | Type of model | Heterogeneity | Test of Association | |||
---|---|---|---|---|---|---|---|---|
I2 | P het | OR | 95% CI | P meta | ||||
rs4950928 | ||||||||
Overall | Recessive model | GG vs. GC + CC | F | 0.00% | 0.430 | 0.946 | 0.626–1.428 | 0.791 |
Dominant model | GG + GC vs. CC | R | 86.70% | 0.000 | 0.917 | 0.767–1.097 | 0.342 | |
Codominant model | GC vs. CC | R | 85.80% | 0.000 | 0.915 | 0.759–1.103 | 0.351 | |
Homozygote model | GG vs. CC | F | 39.10% | 0.160 | 0.889 | 0.588–1.346 | 0.579 | |
Allele model | G vs. C | R | 84.90% | 0.000 | 0.933 | 0.802–1.085 | 0.369 | |
Caucasians | Recessive model | GG vs. GC + CC | F | 21.40% | 0.128 | 0.794 | 0.475–1.327 | 0.378 |
Dominant model | GG + GC vs. CC | R | 70.20% | 0.035 | 0.621 | 0.484–0.797 | 0.000 | |
Codominant model | GC vs. CC | R | 65.70% | 0.054 | 0.612 | 0.470–0.796 | 0.000 | |
Homozygote model | GGvs. CC | F | 40.40% | 0.187 | 0.675 | 0.402–1.134 | 0.138 | |
Allele model | G vs. C | R | 68.70% | 0.041 | 0.696 | 0.567–0.856 | 0.001 | |
Children | Recessive model | GG vs. GC + CC | F | 28.00% | 0.249 | 0.844 | 0.529-1.346 | 0.476 |
Dominant model | GG + GC vs. CC | R | 91.90% | 0.000 | 0.955 | 0.782–1.166 | 0.651 | |
Codominant model | GC + CC | R | 90.90% | 0.000 | 0.970 | 0.788-1.196 | 0.777 | |
Homozygote model | GG vs. CC | R | 64.00% | 0.062 | 0.797 | 0.499-1.275 | 0.345 | |
Allele model | G vs. C | R | 91.30% | 0.000 | 0.946 | 0.799–1.120 | 0.522 | |
rs10494132 | ||||||||
Overall | Recessive model | TT vs. TC + CC | F | 35.80% | 0.182 | 1.212 | 0.981–1.497 | 0.075 |
Dominant model | TT + TC vs. CC | F | 21.80% | 0.276 | 0.857 | 0.597–1.230 | 0.403 | |
Codominant model | TC vs. CC | F | 0.00% | 0.455 | 0.748 | 0.504–1.109 | 0.149 | |
Homozygote model | TT vs. CC | F | 24.70% | 0.257 | 0.916 | 0.630–1.331 | 0.646 | |
Allele model | T vs. C | R | 57.90% | 0.050 | 1.094 | 0.924–1.297 | 0.298 | |
Asians | Recessive model | TT vs. TC + CC | F | 29.80% | 0.240 | 1.476 | 1.071–2.032 | 0.017 |
Dominant model | TT + TC vs. CC | F | 48.10% | 0.145 | 1.125 | 0.654–1.933 | 0.671 | |
Codominant model | TC vs. CC | F | 24.60% | 0.266 | 0.926 | 0.507–1.691 | 0.802 | |
Homozygote model | TT vs. CC | F | 48.90% | 0.141 | 1.249 | 0.709-2.199 | 0.441 | |
Allele model | T vs. C | R | 64.00% | 0.062 | 1.326 | 1.024–1.717 | 0.032 | |
Children | Recessive model | TT vs. TC + CC | F | 30.60% | 0.263 | 1.472 | 1.067–2.030 | 0.019 |
Dominant model | TT + TC vs. CC | F | 53.00% | 0.119 | 1.101 | 0.629–1.927 | 0.737 | |
Codominant model | TC vs. CC | F | 34.70% | 0.216 | 0.903 | 0.485–1.681 | 0.748 | |
Homozygote model | TT vs. CC | F | 53.30% | 0.117 | 1.217 | 0.679–2.184 | 0.510 | |
Allele model | T vs. C | R | 64.90% | 0.058 | 1.320 | 1.016–1.713 | 0.037 |