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Table 3 The serial changes of pressure settings of mechanical ventilation and index of arterial oxygenation during and after removal of venovenous extracorporeal membrane oxygenation

From: The impacts of baseline ventilator parameters on hospital mortality in acute respiratory distress syndrome treated with venovenous extracorporeal membrane oxygenation: a retrospective cohort study

 

24 h after ECMO institution

(T2)

Just before ECMO removal.

(T3)

24 h after ECMO removal

(T4)

Survivors (n = 50)

 PaO2/FiO2 (mmHg)

226 ± 85*

206 ± 89

216 ± 94

 Peak inspiratory pressure (cmH2O)

30 ± 5

30 ± 5

24 ± 13

 Mean airway pressure (cmH2O)

17 ± 3

17 ± 4

17 ± 4

 PEEP (cmH2O)

12 (10–14)

10 (10–12)

12 (10–12)

 Dynamic driving pressurea (cmH2O)

18 ± 6

19 ± 5

19 ± 6

 Measured tidal volume (ml/kg)

7 ± 1

8 ± 2

7 ± 4

 Dynamic complianceb (ml/cmH2O)

24 ± 9*

28 ± 12

22 ± 15

 Oxygen indexc

8 ± 4*

10 ± 6

10 ± 6

 ECMO outflow PaO2 (mmHg)

391 (338–449)

50 (38–133)

 ECMO outflow PaCO2 (mmHg)

35 (28–40)

40 (36–59)

 ECMO outflow O2 saturation (%)

100

100

Non-Survivors (n = 56)

  

 PaO2/FiO2 (mmHg)

164 ± 84*

 Peak inspiratory pressure (cmH2O)

32 ± 5

 Mean airway pressure (cmH2O)

18 ± 4

 PEEP (cmH2O)

13 ± 3

 Dynamic driving pressurea (cmH2O)

19 ± 6

 Measured tidal volume (ml/kg)

6 ± 3

 Dynamic complianceb (ml/cmH2O)

19 ± 10*

 Oxygen indexc

14 ± 7*

 ECMO outflow PaO2 (mmHg)

408 ± 79

 ECMO outflow PaCO2 (mmHg)

36 ± 6

 ECMO outflow O2 saturation (%)

100

  1. Only the survivors showed data recorded just before and 24 h after ECMO removal
  2. Data were presented as mean ± standard deviation in normal-distributed numerical variables, median (interquartile range) in numerical variables not normal-distributed, and n (%) in categorical variables. ECMO Extracorporeal membrane oxygenation, PEEP Positive end expiratory pressure
  3. *The mean values of a specific variable in the T2 column are significant different between the survivors and non-survivors while analyzed by independent T-test (p < 0.05)
  4. aDriving pressure = (Peak inspiratory pressure – Positive end-expiratory pressure)
  5. bDynamic pulmonary compliance = Measured tidal volume/ Driving pressure
  6. cOxygen index = [(Mean airway pressure□x□FiO2□× 100)/ arterial oxygen tension]