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Table 2 Correlation of NT-proBNP with hemodynamics and functional capacity according to gender, age and PH class

From: The association of N-terminal pro-brain-type natriuretic peptide with hemodynamics and functional capacity in therapy-naive precapillary pulmonary hypertension: results from a cohort study

  

Gender

Age

PH group

 

Total

male

female

≤ 65

> 65

PAH

CTEPH

 

n = 84

n = 38

n = 46

n = 24

n = 60

n = 63

n = 12

 

r

r

r

r

r

r

r

6MWT

       

 Distance (m)

−0.430***

−0.435**

−0.395**

−0.246

−0.403**

−0.507***

−0.175

 % of norm

−0.448***

−0.476**

−0.467**

−0.295

−0.486***

−0.556***

0.091

 Breaks (n)

−0.497***

0.513**

0.468**

0.173

0.507***

0.556***

0.063

 Borg scale

0.299**

0.283

0.340*

0.042

0.328**

0.271*

0.573

RHC

       

 mPAP (mmHg)

0.386***

0.454**

0.318*

0.046

0.581***

0.341**

0.900***

 CO (l/min)

−0.342**

−0.338*

−0.335*

−0.495*

−0.282*

−0,322*

−0.625*

 CI (l/min/m2)

−0.252

−0.183

−0.251

−0.261

−0.255

−0,384*

−0.100

 PVR (Wood units)

0.460***

0.543**

0.458**

0.327

0.598***

0.488***

0.918***

 mRAP (mmHg)

0.243*

0.255

0.231

0.045

0.270

0.215

0.260

 SvO2 (%)

−0.527***

−0.572***

−0.491**

0.127

−0.544***

−0.530***

−0.528

Lung function

       

 DLCO (%)

−0.251

−0.190

−0.385*

−0.044

−0.227

−0.332*

−0.200

 PaO2 rest (mmHg)

−0.250*

−0.240

−0.307*

−0.087

−0.237

−0.312*

0.284

 PaO2 exercise (mmHg)

−0.166

−0.056

−0.233

−0.109

−0.142

−0.221

0.186

CPET

       

 Work (watts)

−0.424***

−0.280

−0.533***

−0.364

−0.401**

−0.438***

−0.173

 VO2 (ml/min)

−0.430***

−0.479**

−0.375*

−0.417

−0.420**

−0.492***

−0.035

 VO2/kg

−0.434***

−0.471**

−0.375*

−0.220

−0.462***

−0.514***

−0.100

 AT (ml/min/kg)

−0.294*

−0.379*

−0.172

−0.319

−0.302*

−0.307

−0.618*

 O2 pulse (ml/min/beat)

−0.409***

−0.329*

−0.497***

−0.329

−0.459***

−0.373**

−0.615*

 Ve (L/min)

0.007

−0.021

0.001

−0.081

0.079

−0.024

0.119

 Ve/VO2

0.384**

0.336

0.392*

0.791***

0.280*

0.479***

−0.091

 Ve/VCO2

0.451***

0.351*

0.484**

0.591*

0.386**

0.465**

0.519

 AaDO2 (mmHg)

0.398***

0.354*

0.437**

0.373

0.394**

0.452***

0.221

 Vd/Vt (%)

0.351**

0.266

0.463**

0.274

0.352**

0.349**

0.460

 Ve/VCO2 slope

0.427***

0.445**

0.433**

0.470*

0.441***

0.471***

0.671*

  1. Level of significance: * p < 0.05; ** p < 0.01; *** p < 0.001
  2. PH: pulmonary hypertension, IPAH: idiopathic pulmonary arterial hypertension, CTEPH: chronic thromboembolic pulmonary hypertension, 6MWT: 6 min walking test, RHC: right heart catheterisation, PAP: pulmonary arterial pressure,
  3. PVR: pulmonary vascular resistance, RAP: right atrial pressure, SvO 2: mixed venous oxygen saturation, DLCO: lung diffusing capacity for carbon monoxide,
  4. PaO 2: arterial oxygen pressure, VO 2: peak oxygen uptake, AT: anaerobic threshold, Ve: peak minute ventilation, Ve/VO 2: oxygen equivalent at anaerobic threshold,
  5. Ve/VCO 2: carbon dioxide equivalent at anaerobic threshold, AaDO 2: alveolar-arterial oxygen difference at peak exercise, Vd/Vt: functional dead space ventilation at peak exercise, Ve/VCO 2 slope: slope of minute ventilation to carbon dioxide output
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BMC Pulmonary Medicine

ISSN: 1471-2466

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