Fig. 6

MALAT1 silencing induced apoptosis in A549 cells. a q-PCR verification of CDC6 expression in BPD patients compared with normal. Y-axis showed normalized relative expression level of CDC6. *, P < 0.05. b A549 cells were transfected with shMALAT1 or shRNA negative control, and CDC6 expression level was compared among blank (no shRNA), sh-NC (shRNA negative control_and sh-MALAT1 (MALAT1 shRNA).Y-axis showed normalized relative expression level of CDC6. **, P < 0.01. PI/Annexin-FITC apoptosis assay. The apoptosis rate of Blank, sh-NC and sh-MALAT1 was (0.94 ± 0.03), (1.96 ± 0.01) and (5.18 ± 0.65), respectively. Profiles of (c-e) are representative of at least three independent experiments. Statistical analysis is shown in (f) (p < 0.01)