Value at the start of | ||||
---|---|---|---|---|
Variable | Value at enrollment | Placebo | Glycine | p* |
Gender (male: female) | 5:8 | – | – | – |
Age (years) | 13.0 ± 5.4 | – | – | – |
BMI (kg/m 2 ) | 15.9 ± 1.5 | 16.1 ± 1.6 | 15.8 ± 1.5 | 0.32 |
Respiratory rate (breaths/min) | 25.3 ± 4.8 | 22.8 ± 2.6 | 26.5 ± 5.0 | 0.015 |
Questionnaire scorea | 11.1 ± 3.6 | 10.1 ± 3.1 | 11.1 ± 3.1 | 0.21 |
SpO2 (%) | 89.5 ± 7.5 | 92.8 ± 2.8 | 88.4 ± 7.6 | 0.032 |
FVC (% of predicted) | 79.1 ± 30.8 | 84.0 ± 25.2 | 79.5 ± 28.0 | 0.34 |
FEV1 (% of predicted) | 65.3 ± 34.4 | 66.8 ± 30.6 | 58.7 ± 27.9 | 0.25 |
FEV1/FVC (% of predicted) | 80.4 ± 16.6 | 79.8 ± 14.7 | 74.1 ± 14.0 | 0.17 |
Serum glycine (μg/ml) | 121.9 ± 23.3 | 131.8 ± 16.4 | 153.7 ± 35.1 | 0.29 |