Table 1 Clinicopathological characteristics of patients
Variables | Cohort 1 (N = 604) | Cohort 2 (N = 333) | P-value |
|---|---|---|---|
Age (median), years | 70 (33–90) | 68 (19–87) | 0.057 |
Sex (male/female) | 376(62.3%)/228(37.7%) | 181(54.4%)/152(45.6%) | 0.022 |
Smoking history (current/former/never) | 176(29.1%)/215(35.6%)/ 213(35.3%) | 92(27.6%)/104(31.2%)/ 137(41.1%) | 0.188 |
FEV1%, % | 72.1 (33.4–157.4) | 74.1 (31.5–100.0) | 0.031 |
%VC, % | 107.7 (49.8–156.0) | 103.8 (56.9–171.8) | 0.004 |
Resected side (right/left) | 359(59.4%)/245(40.6%) | 137(41.1%)/196(58.9%) | 0.890 |
Surgical procedures (Pneumo/Lob/Seg) | 4(0.7%)/467(77.3%)/ 133(22.0%) | 1(0.3%)/293(88.0%)/ 39(11.7%) | <0.001 |
Clinical stage (I/II/IIIA) | 470(77.8%)/98(16.2%)/ 36(6.0%) | 253(76.0%)/41(12.3%)/ 39(11.7%) | 0.005 |
Clinical T factor (T1/T2/T3/T4) | 377(62.4%)/200(33.1%)/ 24(4.0%)/3(0.5%) | 200(60.1%)/110(33.0%)/ 16(4.8%)/7(2.1%) | 0.137 |
Clinical N factor (N0/N1/N2) | 517(85.6%)/58(9.6%)/ 29(4.8%) | 282(84.7%)/17(5.1%)/ 34(10.2%) | 0.001 |
Pathological stage (I/II/IIIA) | 457(75.7%)/86(14.2%)/ 61(10.1%) | 240(72.1%)/42(12.6%)/ 51(15.3%) | 0.061 |
Pathological T factor (T1/T2/T3/T4) | 351(58.1%)/228(37.7%)/ 24(4.0%)/1(0.2%) | 192(57.7%)/117(35.1%)/ 16(4.8%)/8(2.4%) | 0.009 |
Pathological N factors (N0/N1/N2) | 489(81.0%)/58(9.6%)/ 57(9.4%) | 267(80.2%)/21(6.3%)/ 45(13.5%) | 0.049 |
Histology (Ad/Sq/others) | 440(72.8%)/123(20.4%)/ 41(6.8%) | 260(78.1%)/55(16.5%)/ 18(5.4%) | 0.180 |
Neutrophil counts (mean ± SD), mm-3 | 3800 ± 1400 | 3800 ± 1700 | 0.595 |
Lymphocyte counts (mean ± SD), mm-3 | 1700 ± 600 | 1700 ± 600 | 0.716 |
NLR (mean ± SD) | 2.5 ± 1.5 | 2.6 ± 1.8 | 0.526 |
CEA (mean ± SD), ng/ml | 7.0 ± 23.9 | 6.7 ± 22.0 | 0.830 |
CYFRA 21-1 (mean ± SD), ng/ml | 1.9 ± 2.3 | 1.9 ± 3.1 | 0.886 |
ILD (UIP/non-UIP pattern) | 35(5.8%, 7/28) | 44(13.2%, 9/35) | <0.001 |
Postoperative adjuvant chemotherapy | 199(32.9%) | 170(51.1%) | <0.001 |
Recurrences of lung cancer | 125(20.7%) | 84(25.2%) | 0.119 |
Cause of death (lung cancer/others/ unknown) | 65(10.8%)/75(12.4%)/ 11(1.8%) | 38(11.4%)/28(8.4%)/ 6(1.8%) | 0.306 |