Development and validation of a preoperative prognostic index independent of TNM stage in resected non-small cell lung cancer

Table 2 Prognostic impacts on overall survival in NSCLC in cohort 1

Univariate analysis		HR	95% CI			P-value
Age	≥70	2.39	1.69	–	3.36	<0.001
Sex	Male	3.29	2.15	–	5.02	<0.001
Smoking history	Ever	4.74	2.90	–	7.76	0.005
FEV1%	<70%	1.62	1.17	–	2.22	0.003
%VC	<80%	3.77	2.30	–	6.19	<0.001
NLR	≥2.1	2.31	1.60	–	3.32	<0.001
CEA (ng/mL)	>normal limit	2.11	1.50	–	2.96	<0.001
CYFRA21-1 (ng/mL)	>normal limit	3.85	2.51	–	5.91	<0.001
ILD^a	Non-UIP	5.22	3.21	–	8.49	<0.001
	UIP	10.3	4.53	–	23.5	<0.001
Multivariate analysis		HR	95% CI			P-value
Age	≥70	1.65	1.16	–	2.36	0.005
Sex	Male	0.91	0.49	–	1.69	0.773
Smoking history	Ever	3.25	1.59	–	6.61	0.001
FEV1%	<70%	1.40	0.99	–	1.97	0.055
%VC	<80%	2.12	1.25	–	3.60	0.005
NLR	≥2.1	1.82	1.25	–	2.66	0.002
CEA (ng/mL)	>normal limit	1.39	0.97	–	1.97	0.070
CYFRA21-1 (ng/mL)	>normal limit	1.76	1.11	–	2.80	0.017
ILD^a	Non-UIP	3.54	2.08	–	6.01	<0.001
	UIP	7.33	3.09	–	17.4	<0.001

Abbreviations: NSCLC, non-small cell lung cancer; HR, hazard ratio; 95% CI, 95% confidence interval; NLR, neutrophil to lymphocyte ratio; CEA, carcinoembryonic antigen; CYFRA 21-1, cytokeratin 19 fragment; ILD, interstitial lung disease; UIP, usual interstitial pneumonia
^aThe without-ILD group served as a reference group

ISSN: 1471-2466