Table 4 Pooled means of sensitivity and specificity, diagnostic odds ratio(DOR), area under the curve(AUC), and calculated likelihood ratios for each interleukin
Interleukins | sensitivity(95%CI) | specificity(95%CI) | DOR | AUC | PLR | NLR |
|---|---|---|---|---|---|---|
IL-27 | 0.93(0.90–0.95) | 0.95(0.90–0.98) | 264 | 0.95 | 19.5(9.4–40.5) | 0.07(0.05–0.11) |
IL-18 | 0.87(0.79–0.92) | 0.92 (0.88–0.95) | 76 | 0.95 | 10.8 (7.2–16.3) | 0.14(0.09–0.23) |
IL-6 | 0.86(0.70–0.94) | 0.84(0.74–0.90) | 30 | 0.90 | 5.2(3.0–9.1) | 0.17(0.07–0.41) |
IL-33 | 0.84(0.77–0.89) | 0.80(0.65–0.89) | 20 | 0.88 | 4.2(2.21–7.9) | 0.20(0.13–0.32) |
IL-12 | 0.78(0.69–0.84) | 0.83(0.72–0.91) | 17 | 0.86 | 4.6(2.8–7.8) | 0.27(0.20–0.37) |
IL-2 | 0.67(0.61–0.73) | 0.76(0.70–0.82) | 11 | 0.86 | 3.4(1.7–6.8) | 0.36(0.20–0.66) |
IL-12p40 | 0.82(0.66–0.91) | 0.65(0.54–0.74) | 8 | 0.76 | 2.3(1.6–3.4) | 0.28(0.13–0.61) |