Skip to main content

Table 1 Characteristics, laboratory values, and outcomes of patients with and without ARDS included in the study

From: Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts

 

Patients with ARDS

Patients without ARDS

P-value

Number

39

368

 

Age

57.0 (45.0–67.0)

62.0 (50.0–72.0)

0.07

Female

13 (33.3)

139 (37.8)

0.59

Study site

  

0.40

Korea

18 (46.2)

132 (35.9)

 

New York

7 (18.0)

92 (25.0)

 

Boston

14 (35.9)

144 (39.1)

 

APACHE IIa

27.0 (21.0–33.0)

22.0 (15.0–28.0)

< 0.001

Sepsisb

16 (41.0)

170 (46.2)

0.54

Septic shock

8 (20.5)

53 (14.4)

0.31

Pneumonia

34 (87.2)

101 (27.5)

< 0.001

Intubation

35 (89.7)

181 (49.2)

< 0.001

Procalcitonin, ng/mLc

7.6 (2.6–33.2)

0.9 (0.2–3.7)

< 0.001

Creatinine, mg/dLa

0.8 (0.6–1.6)

1.0 (0.7–1.5)

0.28

Bilirubin, mg/dLa

1.05 (0.6–3.0)

0.7 (0.5–1.1)

0.14

pH in arterial blooda

7.35 (7.28–7.45)

7.39 (7.29–7.46)

0.49

PaO2, mmHga

72.9 (62.8–98.3)

87.7 (69.3–113.3)

0.15

PaCO2, mmHga

36.9 (29.8–44.9)

32.4 (26.0–40.9)

0.07

Lactate, mEq/L

2.4 (1.5–3.5)

2.0 (1.3–3.4)

0.24

Albumin, g/dL

2.5 (2.1–2.9)

2.9 (2.4–3.5)

0.009

SP-D, ng/mL

20.8 (12.7–38.4)

7.9 (4.0–17.0)

< 0.01

Length of ICU stay

8.0 (5.0–15.0)

3.0 (2.0–6.0)

< 0.001

ICU-mortality

7 (17.9)

28 (7.6)

0.008

Hospital-mortality

14 (35.9)

50 (13.6)

< 0.001

  1. Abbreviations: ARDS acute respiratory distress syndrome, COPD Chronic Obstructive Pulmonary Disease, APACHE Acute Physiology and Chronic Health Evaluation, PaO 2 arterial oxygen tension, PaCO2 arterial carbon dioxide tension, SP-D Surfactant protein D, ICU intensive care unit
  2. Data are presented as median (interquartile range) or as number (%)
  3. aAt admission to medical ICU
  4. bIt does not include patients with septic shock
  5. cData are available for 91 patients (13 patients with and 78 patients without ARDS)