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Table 1 Characteristics, laboratory values, and outcomes of patients with and without ARDS included in the study

From: Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts

  Patients with ARDS Patients without ARDS P-value
Number 39 368  
Age 57.0 (45.0–67.0) 62.0 (50.0–72.0) 0.07
Female 13 (33.3) 139 (37.8) 0.59
Study site    0.40
Korea 18 (46.2) 132 (35.9)  
New York 7 (18.0) 92 (25.0)  
Boston 14 (35.9) 144 (39.1)  
APACHE IIa 27.0 (21.0–33.0) 22.0 (15.0–28.0) < 0.001
Sepsisb 16 (41.0) 170 (46.2) 0.54
Septic shock 8 (20.5) 53 (14.4) 0.31
Pneumonia 34 (87.2) 101 (27.5) < 0.001
Intubation 35 (89.7) 181 (49.2) < 0.001
Procalcitonin, ng/mLc 7.6 (2.6–33.2) 0.9 (0.2–3.7) < 0.001
Creatinine, mg/dLa 0.8 (0.6–1.6) 1.0 (0.7–1.5) 0.28
Bilirubin, mg/dLa 1.05 (0.6–3.0) 0.7 (0.5–1.1) 0.14
pH in arterial blooda 7.35 (7.28–7.45) 7.39 (7.29–7.46) 0.49
PaO2, mmHga 72.9 (62.8–98.3) 87.7 (69.3–113.3) 0.15
PaCO2, mmHga 36.9 (29.8–44.9) 32.4 (26.0–40.9) 0.07
Lactate, mEq/L 2.4 (1.5–3.5) 2.0 (1.3–3.4) 0.24
Albumin, g/dL 2.5 (2.1–2.9) 2.9 (2.4–3.5) 0.009
SP-D, ng/mL 20.8 (12.7–38.4) 7.9 (4.0–17.0) < 0.01
Length of ICU stay 8.0 (5.0–15.0) 3.0 (2.0–6.0) < 0.001
ICU-mortality 7 (17.9) 28 (7.6) 0.008
Hospital-mortality 14 (35.9) 50 (13.6) < 0.001
  1. Abbreviations: ARDS acute respiratory distress syndrome, COPD Chronic Obstructive Pulmonary Disease, APACHE Acute Physiology and Chronic Health Evaluation, PaO 2 arterial oxygen tension, PaCO2 arterial carbon dioxide tension, SP-D Surfactant protein D, ICU intensive care unit
  2. Data are presented as median (interquartile range) or as number (%)
  3. aAt admission to medical ICU
  4. bIt does not include patients with septic shock
  5. cData are available for 91 patients (13 patients with and 78 patients without ARDS)