Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts

Table 2 Characteristics, laboratory values, and outcomes of cases (patients with ARDS) and matched controls (patients without ARDS) included in the propensity score matched analysis

	Cases (patients with ARDS)	Controls (patients without ARDS)	P-value
Number	38	38
Age	57.0 (45.0–67.0)	62.0 (50.0–72.0)	0.53
Female	13 (34.2)	13 (34.2)	1.00
Study site			0.16
Korea	18 (46.2)	10 (25.6)
New York	7 (17.9)	10 (25.6)
Boston	14 (35.9)	19 (48.7)
APACHE II^a	27.5 (24.0–33.0)	26.0 (18.0–35.0)	0.62
Sepsis^b	16 (42.1)	33 (86.8)	<0.001
Septic shock	7 (18.4)	4 (10.5)	0.33
Pneumonia	33 (86.8)	33 (86.8)	1.00
Intubation	34 (89.5)	32 (84.2)	0.55
Procalcitonin, ng/mL^c	6.0 (2.1–36.4)	0.8 (0.2–4.8)	0.03
Creatinine, mg/dL^a	0.8 (0.6–1.6)	1.0(0.7–1.9)	0.48
Bilirubin, mg/dL^a	1.0 (0.6–3.0)	3.1 (0.5–6.1)	0.61
pH in arterial blood^a	7.34 (7.28–7.45)	7.40 (7.28–7.46)	0.79
PaO₂, mmHg^a	72.9 (62.8–98.3)	87.7 (69.3–113.3)	0.92
PaCO₂, mmHg^a	36.9 (29.8–44.9)	32.4 (26.0–40.9)	0.82
Lactate, mEq/L	2.4 (1.5–3.5)	2.0 (1.3–3.4)	0.23
Albumin, g/dL	2.5 (2.1–3.0)	2.9 (2.4–3.5)	0.2
SP-D, ng/mL	20.8 (12.7–38.4)	7.9 (4.1–17.0)	0.001
Length of ICU stay	8.0 (5.0–15.0)	4.0 (2.0–10.0)	0.006
ICU Mortality	7 (18.4)	6 (15.8)	0.76
In-hospital Mortality	14 (35.9)	10 (26.3)	0.32

Abbreviations: ARDS acute respiratory distress syndrome, APACHE Acute Physiology and Chronic Health Evaluation, PaO ₂ arterial oxygen tension, PaCO ₂ arterial carbon dioxide tension, SP-D Surfactant protein D, ICU intensive care unit
Data are presented as median (interquartile range) or as number (%)
^aAt admission to medical ICU
^bIt does not include patients with septic shock
^cData are available for 19 patients (12 patients with and 7 patients without ARDS)

ISSN: 1471-2466