Table 4 Symptomatic and Radiographic Changes, Clarithromycin Resistance, and Treatment for Newly Isolated NTM
From: Implication of species change of Nontuberculous Mycobacteria during or after treatment
No | NTM spices | Symptom changes at isolation of new NTM | Radiographic changes at isolation of new NTM | Clarithromycin resistance for initial NTM (MIC, μg/ml) | Clarithromycin resistance for new NTM(MIC, μg/ml) | Timing of new NTM isolation | Treatment for newly isolated NTM |
|---|---|---|---|---|---|---|---|
M. avium complex → M. abscessus subspecies abscessus | |||||||
1 | M. intracellulare → M. abscessus subspecies abscessus | Worsening | Worsening | Susceptible (1) | Inducible resistance (1, 64) | After treatment for initial NTM | Not started |
2 | M. intracellulare → M. abscessus subspecies abscessus | Worsening | Unchanged | Susceptible (2) | Inducible resistance (2, 64) | During treatment for initial NTM | aStarted |
`3 | M. intracellulare → M. abscessus subspecies abscessus | Worsening | Worsening | Susceptible (2) | Inducible resistance (2, 8) | After treatment for initial NTM | Not started |
4 | M. intracellulare → M. abscessus subspecies abscessus | Worsening | Worsening | Susceptible (2) | Inducible resistance (0.5, 64) | After treatment for initial NTM | Not started |
5 | M. avium → M. abscessus subspecies abscessus | Unchanged | Unchanged | Susceptible (4) | Inducible resistance (0.5, 64) | During treatment for initial NTM | Not started |
6 | M. avium → M. abscessus subspecies abscessus | Worsening | Worsening | Susceptible (1) | Inducible resistance (1, 64) | During treatment for initial NTM | Continued on-going treatment |
7 | M. avium → M. abscessus subspecies abscessus | Worsening | Unchanged | Susceptible (0.5) | Inducible resistance (1, 64) | During treatment for initial NTM | Modified regimen and continued treatment |
M. abscessus subspecies massiliense → M. avium complex | |||||||
8 | M. abscessus subspecies massiliense → M. intracellulare | Unchanged | Unchanged | Susceptible (0.5) | N/A | During treatment for initial NTM | Modified regimen and continued treatment |
9 | M. abscessus subspecies massiliense → M. intracellulare | Unchanged | Worsening | Susceptible (0.5) | Susceptible (1) | During treatment for initial NTM | Modified regimen and continued treatment |
10 | M. abscessus subspecies massiliense → M. avium | Unchanged | Unchanged | Susceptible (0.5) | Resistance (64) | During treatment for initial NTM | Continued on-going treatment |
11 | M. abscessus subspecies massiliense → M. avium | Unchanged | Improving | Susceptible (0.5) | Susceptible (2) | During treatment for initial NTM | Modified regimen and continued treatment |
12 | M. abscessus subspecies massiliense → M. avium | Unchanged | Unchanged | N/A | N/A | During treatment for initial NTM | aStarted |
Others | |||||||
13 | M. avium → M. fortuitum | Unchanged | Improving | Susceptible (0.5) | Inducible resistance (0.5, 16) | During treatment for initial NTM | Not started |
14 | M. avium → M. intracellulare | Worsening | Worsening | N/A | Susceptible (1) | After treatment for initial NTM | Started |
15 | M. intracellulare → M. chimerae | Improving | Worsening | Susceptible (1) | Susceptible (2) | During treatment for initial NTM | Continued on-going treatment |
16 | M. abscessus subspecies massiliense → M. abscessus subspecies abscessus | Unchanged | Worsening | Susceptible (0.5) | Inducible resistance (1, 16) | During treatment for initial NTM | Continued on-going treatment |