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Table 2 Multiple breath washout data (n = 103)

From: Multiple breath washout testing in adults with pulmonary disease and healthy controls – can fewer measurements eventually be more?

  

Triplicate measurements

Duplicate measurements

p-value#

  

Mean ± SD

Range

CV ± SD

Mean ± SD

Range

CV ± SD

Means

CVs

Control

         

 LCI

 

7.4 ± 0.8

6.0 – 8.6

2.5 ± 1.8

7.4 ± 0.8

5.9 – 8.6

2.7 ± 2.1

0.6

0.6

 FRCMBW

l

3.0 ± 0.6

1.9 – 4.2

3.6 ± 3.0

2.9 ± 0.6

1.8 – 4.1

4.1 ± 3.9

0.5

0.3

 Test time

s

469 ± 134

211 – 709

 

314 ± 85

141 – 467

 

<0.0001

 

COPD

        

 LCI

 

10.8 ± 2.2

8.0 – 17.6

3.6 ± 1.8

10.9 ± 2.2

7.8 – 17.0

3.1 ± 2.3

0.7

0.1

 FRCMBW

l

3.0 ± 0.8

1.5 – 4.8

4.0 ± 4.0

2.9 ± 0.8

1.5 – 4.8

2.7 ± 3.3

0.1

<0.05

 Test time

s

592 ± 182

294 – 1165

 

392 ± 122

191 – 775

 

<0.0001

 

Asthma

        

 LCI

 

9.2 ± 1.9

5.9 – 13.6

3.3 ± 1.7

9.2 ± 1.9

5.9 – 13.9

3.1 ± 2.4

0.1

0.4

 FRCMBW

l

2.4 ± 0.7

1.0 – 4.1

3.9 ± 3.9

2.4 ± 0.7

1.0 – 4.2

4.1 ± 4.8

0.2

0.7

 Test time

s

462 ± 153

242 – 1022

 

307 ± 101

172 – 690

 

<0.0001

 

Sarcoidosis

        

 LCI

 

8.1 ± 1.2

5.8 – 11.3

2.7 ± 1.7

8.2 ± 1.2

5.8 – 11.1

2.2 ± 2.3

0.4

0.1

 FRCMBW

l

2.9 ± 0.7

1.5 – 4.0

3.8 ± 3.3

2.9 ± 0.7

1.5 – 4.1

3.4 ± 3.4

0.3

0.5

 Test time

s

500 ± 174

228 – 970

 

328 ± 156

156 – 622

 

<0.0001

 

Overall

        

 LCI

 

9.2 ± 2.2

5.8 – 17.6

3.1 ± 1.8

9.2 ± 2.2

5.8 – 17.0

2.9 ± 2.3

0.2

<0.05

 FRCMBW

l

2.8 ± 0.8

1.0 – 4.8

3.9 ± 3.6

2.8 ± 0.8

1.0 – 4.8

3.5 ± 3.9

<0.05

0.2

 Test time

s

510 ± 171

211 – 1165

 

338 ± 112

141 – 775

 

<0.0001

 
  1. LCI lung clearance index, FRC MBW functional residual capacity in multiple breath washout, SD standard deviation, CV coefficient of variation [%], CI 95%-confidence interval
  2. # p-values between means of measurement groups were calculated using paired Student’s t-test