Table 3 Pathways significantly associated with protein-protein interaction nodes
From: Gene expression analysis in asthma using a targeted multiplex array
Pathway name | Hits/Total | FDR |
|---|---|---|
Up-Regulated Pathways | ||
Degradation of Collagen | 4/61 | 0.003 |
Extracellular Matrix Organization | 5/157 | 0.003 |
Degradation of Extracellular Matrix | 4/77 | 0.004 |
Assembly of Collagen Fibrills and Other Multimeric Structures | 3/54 | 0.04 |
Collagen Biosynthesis and Modifying Enzymes | 3/62 | 0.04 |
Down-regulated pathways | ||
Integrin Cell Surface Interactions | 6/85 | 0.0007 |
Signal Transduction | 17/1690 | 0.004 |
Cell-Cell Communication | 6/143 | 0.004 |
Platelet Activation, Signaling, and Aggregation | 7/220 | 0.004 |
TGF-beta Receptor Signaling in EMT | 3/17 | 0.009 |
Hemostatis | 9/511 | 0.01 |
Signaling by TGF-beta Receptor Complex | 4/70 | 0.02 |
Sema4D Induced Cell Migration and Growth-Cone Collapse | 3/29 | 0.03 |
Sema4D in Semaphorin Signaling | 3/34 | 0.04 |
Fc-gamma Receptor Dependent Phagocytosis | 4/86 | 0.04 |