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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Airway administration of corticosteroids for prevention of bronchopulmonary dysplasia in premature infants: a meta-analysis with trial sequential analysis

Fig. 5

Trial sequential analysis of trials reporting primary outcome comparing pooled AACs and placebo. A diversity adjusted information size was calculated using ɑ = 0.05 (two sided), β = 0.20 (power 80%), D2 = 0%, an anticipated relative risk of 29.8%, −24.5%, 13.5%, respectively, and an event proportion of 28.2%, 11.4%, 46.3%, respectively in the control arm. The cumulative z curve was constructed using a random-effect model, and a penalized z curve was also constructed. The adjusted relative risk was 0.71, 0.90, 0.81, respectively, and the 95% confidence interval was corrected to 0.57–0.87, 0.40–2.03, and 0.71–0.97, respectively, AACs: Airway administration of corticosteroids

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