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Fig. 7 | BMC Pulmonary Medicine

Fig. 7

From: Airway administration of corticosteroids for prevention of bronchopulmonary dysplasia in premature infants: a meta-analysis with trial sequential analysis

Fig. 7

Trial sequential analysis of trials reporting primary outcome comparing pooled inhaled corticosteroids and systemic corticosteroids. A diversity adjusted information size was calculated using ɑ = 0.05 (two sided), β = 0.20 (power 80%), D2 = 0%, an anticipated relative risk of −10.5%, 18.4%, respectively, and an event proportion of 36.6%, 20.0%, respectively in the control arm. The cumulative z curve was constructed using a random-effect model, and a penalized z curve was also constructed. The adjusted relative risk was 1.08, 0.81, respectively, and the 95% confidence interval was corrected to 0.53–2.20, 0.43–1.53, respectively

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