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Table 1 Characteristics of 25 RCTs reported in 27 articles and baseline characteristics of patients

From: Airway administration of corticosteroids for prevention of bronchopulmonary dysplasia in premature infants: a meta-analysis with trial sequential analysis

Study

Study characteristics

Group

N

Male (n)

GA (wk)

BW (g)

Antenatal glucocorticoid

RDS (n)

Surfactant(n)

AACs vs placebo

Arnon [35] 1996

1 centre

UK

T

C

15

15

NA

NA

27.5 (0.7)a

27.1 (0.89)a

1024 (92.3)a

1041 (113)a

7 (46.7%)

8 (53.3%)

NA

NA

NA

NA

Bassler [16] 2015

10 centres Switzerland

T

C

437

419

NA

NA

26.1 (1.3)a

26.1 (1.2)a

798 (193)a

803 (189)a

388 (88.8%)

383 (91.4%)

NA

NA

NA

NA

Cao [36] 2016

1 centre

China

T

C

40

40

NA

NA

30.1 (2.2)a

30.7 (1.8)a

1333 (110)a

1339 (105)a

NA

NA

40

40

40

40

Cole [37] 1999

4 centres

USA

T

C

123

130

51

53

26 (2)a

26 (2)a

800 (193)a

802 (189)a

77 (62.6%)

68 (52.3%)

123

129

95

97

Denjean [38] 1998

6 centres

France

T

C

43

43

26

26

27.6 (1.5)a

27.8 (1.6)a

1060 (218)a

1082 (260)a

11 (25.6%)

11 (25.6%)

43

43

31

34

Fok [39] 1999

1 centre

Hong Kong

T

C

27

26

NA

NA

27.9 (0.5)a

27.1 (0.5)a

993 (71)a

981 (71)a

15 (55.6%)

13 (50.0%)

NA

NA

NA

NA

Giep [40] 1996

1 centre

USA

T

C

10

9

6

3

26 (2.0)a

25 (1.6)a

752 (110)a

784 (141)a

4 (40.0%)

2 (22.2%)

8

9

8

9

Jangaard [41] 2002

1 centre

Germany

T

C

30

30

13

13

27.2 (2)a

27.9 (2)a

882 (204)a

917 (178)b

15 (50.0%)

16 (53.3%)

19

25

19

25

Jonsson [42] 2000

1 centre

Sweden

T

C

15

15

8

11

25 (23,27)b

26 (24,29)b

766 (525,1122)b

813 (630,1227)b

12 (80.0%)

10 (66.7%)

14

15

14

15

Ke [43]

2016

1 centre

China

T

C

46

46

20

27

<32

<32

<1500

<1500

NA

NA

46

46

46

46

LaForce [44] 1993

1 centre

USA

T

C

10

11

NA

NA

NA

NA

<1500

<1500

NA

NA

NA

NA

NA

NA

Merz [45] 1999

1 centre

Germany

T

C

12

11

5

7

28 (27,32)b

29 (27,31)b

1108 (820,1420)b

1120 (880,1480)b

7 (58.3%)

7 (63.6%)

12

11

10

9

Nakamura [24] 2016

1 centre

Japan

T

C

107

104

63

50

26 (25,27)b

26 (25,27)b

783.87 (134.8)b

784.06 (127.2)b

45 (42.1%)

42 (40.4%)

90

88

NA

NA

Pappagallo [46] 1998

1 centre

USA

T

C

9

9

5

5

26.8 (1.1)a

26.6 (0.8)a

828 (64)a

849 (89)a

NA

NA

NA

NA

NA

NA

Townsend [47] 1998

1 centre

Denver

T

C

15

17

8

8

25.8

25.5

728

695

NA

NA

15

17

NA

NA

Wen [48] 2016

1 centre

China

T

C

80

80

54

51

30.5 (2.6)a

31.2 (2.3)a

1220 (183)a

1250 (167)a

NA

NA

NA

NA

NA

NA

Yeh [49] 2008

Kuo [50] 2010

1 centre

Taiwan

T

C

60

56

31

29

26.4 (2.2)a

26.7 (2.3)a

881 (245)a

919 (272)a

46 (76.7%)

42 (75.0%)

60

56

60

56

Yeh [25] 2016

1 centre

Taiwan

T

C

131

134

NA

NA

26.5 (2.2)a

26.8 (2.2)a

882 (249)a

935 (283)a

NA

NA

131

134

131

134

Yong [20] 1999

1 centre

UK

T

C

20

20

13

12

27.4 (1.7)a

27.7 (1.7)a

1011 (223)a

932 (401)a

NA

NA

NA

NA

NA

NA

Zimmerman [51] 2000

1 centre

USA

T

C

20

19

12

8

26 (2.0)a

26 (2.0)a

910 (198)a

802 (225)a

14 (70.0%)

15 (78.9%)

15

18

15

18

Inhaled corticosteroids vs systemic corticosteroids

Dimitriou [52] 1997

1 centre

UK

T

C

20

20

NA

NA

27 (24,30)b

27 (24,31)

849 (584,1270)b

818 (425,1460)b

12 (60.0%)

11 (55.0%)

NA

NA

14

12

Groneck [53] 1999

1 centre

Germany

T

C

7

9

3

3

26 (25,28)b

26 (25,28)b

800 (500,1020)b

847 (660,1030)b

NA

NA

NA

NA

NA

NA

Halliday [54] 2001

Wilson [55] 2006

47 centre

Europe

T

C

285

285

142

164

27.2 (1.9)a

27.2 (1.9)a

1002 (281)a

1011 (285)a

177 (62.1%)

164 (57.5%)

NA

NA

265

260

Rozycki [56] 2003

1 centre

USA

T

C

46

15

23

7

<31

<31

<1500

<1500

6 (13.0%)

2 (13.3%)

46

15

46

15

Suchomski [57] 2002

1 centre

USA

T

C

51

27

25

19

26 (1.6)a

26 (2.0)a

844 (157)a

843 (227)a

34 (66.7%)

16 (59.3%)

NA

NA

NA

NA

  1. RCTs Randomized controlled trials, AACs Airway administration of corticosteroids, RDS Respiratory distress syndrome, PS Pulmonary surfactant, AG Antenatal glucocorticoid, GA Gestational age, BW Brith weight, ameans ± SD, bmedian (25th, 75th percentiles), NA: Not Applicated