Study | Age at enrollment | Type of AACS | Intervention dose | Mode of delivery | Intervention treatment |
---|---|---|---|---|---|
AACs vs placebo | |||||
 Arnon [35] 1996 | 15 (0.6)a 14 (0.5)a | BUD | 600 μg BID | MDI | 7 days or until the infant had been extubated |
 Bassler [16] 2015 | within 12 h | BUD | 400 μg Q12H for 14 days 200 μg Q12H for 15 days | MDI | Until extubation and no oxygen dependent or 32 weeks PMA |
 Cao [36] 2016 | within 6 h | BUD | 250 μg Q8H | Airway instillation | Until FIO2 < 0.4 or extubation |
 Cole [37] 1999 | 5.7 (3.4)a 5.4 (2.9)a | BDP | 40 μg/kg for 7 days 30 μg/kg for 7 days 15 μg/kg for 7 days 5-10 μg/kg for 7 days | MDI | 28 days |
 Denjean [38] 1998 | 10 days | BDP | 250 μg Q6H | MDI | 28 days |
 Fok [39] 1999 | within 24 h of birth | FPP | 250 μg Q12H | MDI | 14 days |
 Giep [40] 1996 | 14 days | BDP | 1 mg/kg/d | MDI | 7 days |
 Jangaard [41] 2002 | 3 years | BDP | 0.2 mg/kg/d | MDI | Until 28 days of age |
 Jonsson [42] 2000 | 6 days | BUD | 0.5 mg/times BID | Electronic dosimetric jet nebulizer | 14 days |
 Ke [43] 2016 | within 6 h | BUD | 250 μg Q12H | Airway instillation | Until stop respiratory support |
 LaForce [44] 1993 | 14 days | BDP | 50 μg Q8H | A Whisper Jet nebulizer system | 28 days |
 Merz [45] 1999 | 3 days | BUD | 1.6 mg/d Q6H | MDI | 10 days or until extubation |
 Nakamura [24] 2016 | within 24 h of birth | FPP | 50 μg BID | MDI | Until 6 weeks of age or extubation |
 Pappagallo [46] 1998 | 22.6 (3.0)a 19.1 (1.6)a | DXM | 1 mg/kg Q8H for 7 days 0.5 mg/kg Q8H for 7 days | A jet nebulizer | 10 days |
 Townsend [47] 1998 | at 48-96 h of age | FPP | 500 μg TID | MDI | 28 days or until extubation |
Wen [48] 2016 | within 24Â h of birth | BUD | 0.4Â mg/kg Q12H | MDI | 14Â days |
 Yeh [49] 2008 Kuo [50] 2010 | 2.1 (2.2)a | BUD | 0.25 mg/kg Q8H | Airway instillation | Until the infant required ≤0.4 of FIO2 or until the infant was extubated |
 Yeh [25] 2016 | 2.0 (1.5)a 1.8 (1.6)a | BUD | 0.25 mg/kg Q8H | Airway instillation | Until the infant required ≤0.4 of FIO2 or until extubation |
 Yong [20] 1999 | within 18 h of birth | FPP | 250 μg Q12H | MDI | 14 days |
 Zimmerman [51] 2000 | within 24 h of birth | BDP | 2MDI, Q6H for 3 days; 2MDI, Q8H for 3 days; 2MDI Q12H for 3 days; 2MDI QD for 3 days | MDI | 12 days |
Inhaled corticosteroids vs systemic corticosteroids | |||||
 Dimitriou [52] 1997 | After 5 days | BUD | 100 μg QD | A jet nebulizer | 10 days |
 Groneck [53] 1999 | After 72 h | BDP | 250 μg QD | MDI | 10~28 days |
 Halliday [54] 2001 Wilson [55] 2006 | < 72 h or > 15d | BUD | <1000 g 0.4 mg BID >1000 g 0.6 mg BID | MDI | 12 days or until extubation |
 Rozycki [56] 2003 | at 14 days of age | BDP | High: 2.4-3.7 mg/kg/d Mid: 1.0-1.8 mg/kg/d Low: 0.5-0.7 mg/kg/d | MDI | 7 days or until extubation |
 Suchomski [57] 2002 | 12-21 days of age | BDP | High: 800 μg/d Low: 400 μg/d | MDI | Until extubation |