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Table 5 Structural modifications (basement membrane thickness, disepithelization degree, endothelium) and mucosal inflammatory cells in bronchial biopsies at baseline and after BT

From: Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma

  Friedman tes P value T0 T0 vs T1 P value T1 T0 vs T2 P value T2 T12 T0 vs T12 P value
Submucosa (cells/mm 2 )
CD45 0.99 369 (253–692)   394 (237–796)   425 (313–927) 398 (329–492)  
CD4 0.18 259 (168–312) 0.0096 329 (165–548)   304 (167–600) 196 (167–304)  
CD8 0.52 118 (32–280)   130 (32–281)   134 (13–340) 196 (116–223)  
CD68 0.0024 16 (10–35) 0.0409 27 (13–55) 0.0409 32 (10–74) 61 (26–122) 0.018
Neutrophils 0.08 206 (119–393) 0.0499 250 (193–410)   224 (129–495) 220 (97–277)  
Eosinophils 0.17 39 (11–116)   58 (16–334)   79 (2–131) 211 (10–359)  
Mast Cells (Tryptase) 0.15 112 (32–267) 0.0186 56 (11–258)   77 (28–123) 58 (42–170)  
Endothelial cells-CD31 0.48 365 (240–459)   368 (244–597)   375 (341–525) 365 (309–455)  
Basement membrane thickness, μm 0.87 5.20 (4.1–7.4)   5.02 (3.7–7.1)   5.60 (3.8–7.5) 6.53 (5.34–8.51)  
% Disepithelization 0.404 72 (40–90)   50 (10–95)   70 (35–100) 62 (20–90)  
  1. Legend: Data expressed as median (range). Statistics: Friedman test for comparison among time points, Wilcoxon rank test for comparison between time points (T0 vs T1, T0 vs T2 and T0 vs T12). Only significant values (p < 0.05) are reported