Table 5 Structural modifications (basement membrane thickness, disepithelization degree, endothelium) and mucosal inflammatory cells in bronchial biopsies at baseline and after BT
From: Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma
Friedman tes P value | T0 | T0 vs T1 P value | T1 | T0 vs T2 P value | T2 | T12 | T0 vs T12 P value | |
|---|---|---|---|---|---|---|---|---|
Submucosa (cells/mm 2 ) | ||||||||
CD45 | 0.99 | 369 (253–692) | 394 (237–796) | 425 (313–927) | 398 (329–492) | |||
CD4 | 0.18 | 259 (168–312) | 0.0096 | 329 (165–548) | 304 (167–600) | 196 (167–304) | ||
CD8 | 0.52 | 118 (32–280) | 130 (32–281) | 134 (13–340) | 196 (116–223) | |||
CD68 | 0.0024 | 16 (10–35) | 0.0409 | 27 (13–55) | 0.0409 | 32 (10–74) | 61 (26–122) | 0.018 |
Neutrophils | 0.08 | 206 (119–393) | 0.0499 | 250 (193–410) | 224 (129–495) | 220 (97–277) | ||
Eosinophils | 0.17 | 39 (11–116) | 58 (16–334) | 79 (2–131) | 211 (10–359) | |||
Mast Cells (Tryptase) | 0.15 | 112 (32–267) | 0.0186 | 56 (11–258) | 77 (28–123) | 58 (42–170) | ||
Endothelial cells-CD31 | 0.48 | 365 (240–459) | 368 (244–597) | 375 (341–525) | 365 (309–455) | |||
Basement membrane thickness, μm | 0.87 | 5.20 (4.1–7.4) | 5.02 (3.7–7.1) | 5.60 (3.8–7.5) | 6.53 (5.34–8.51) | |||
% Disepithelization | 0.404 | 72 (40–90) | 50 (10–95) | 70 (35–100) | 62 (20–90) | |||