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Table 3 Genotype and haplotype association analysis in ILVBL gene with the risk of AERD

From: Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

Locus

Diag

Genotype

Codominant.

Dominant.

Recessive

RR

CR

CC

Total

OR [95% CI]

P*

Pcorr **

OR [95% CI]

P*

Pcorr **

OR [95% CI]

P*

Pcorr **

rs2074267

AERD

20 (14.2%)

61 (43.3%)

60 (42.6%)

141 (100%)

0.79 [0.61–1.04]

0.087

0.799

0.67 [0.47–0.96]

0.030

0.273

0.91 [0.55–1.52]

0.729

1.000

ATA

153 (15.4%)

517 (52.0%)

325 (32.7%)

995 (100%)

rs4141356

AERD

31 (22.0%)

64 (45.4%)

46 (32.6%)

141 (100%)

1.33 [1.04–1.72]

0.026

0.235

1.3 [0.89–1.89]

0.174

1.000

1.73 [1.12–2.69]

0.014

0.131

ATA

140 (14.1%)

473 (47.5%)

382 (38.4%)

995 (100%)

rs718100

AERD

30 (21.3%)

61 (43.3%)

50 (35.5%)

141 (100%)

1.43 [1.11–1.85]

0.006

0.050

1.38 [0.95–1.99]

0.089

0.819

2.04 [1.30–3.20]

0.002

0.017

ATA

116 (11.7%)

452 (45.4%)

427 (42.9%)

995 (100%)

rs2074265

AERD

30 (21.3%)

62 (44.0%)

49 (34.8%)

141 (100%)

1.43 [1.11–1.84]

0.006

0.055

1.39 [0.96–2.01]

0.081

0.745

1.98 [1.27–3.11]

0.003

0.026

ATA

119 (12.0%)

454 (45.6%)

422 (42.4%)

995 (100%)

rs2240299

AERD

7 (5.0%)

54 (38.3%)

80 (56.7%)

141 (100%)

0.59 [0.45–0.79]

3.65 × 10−4

0.003

0.57 [0.4–0.82]

0.002

0.020

0.34 [0.16–0.75]

0.007

0.068

ATA

131 (13.2%)

438 (44.1%)

425 (42.8%)

994 (100%)

rs7507755

AERD

7 (5.0%)

54 (38.3%)

80 (56.7%)

141 (100%)

0.59 [0.45–0.79]

3.78 × 10−4

0.003

0.57 [0.4–0.82]

0.002

0.021

0.34 [0.16–0.75]

0.008

0.069

ATA

131 (13.2%)

438 (44.0%)

426 (42.8%)

995 (100%)

rs1468198

AERD

22 (15.6%)

68 (48.2%)

51 (36.2%)

141 (100%)

0.60 [0.47–0.78]

9.53 × 10−4

0.001

0.47 [0.29–0.75]

0.002

0.016

0.53 [0.37–0.78]

0.001

0.010

ATA

279 (28.1%)

483 (48.7%)

230 (23.2%)

992 (100%)

rs2074261

AERD

22 (15.6%)

63 (44.7%)

56 (39.7%)

141 (100%)

0.62 [0.48–0.8]

2.30 × 10−4

0.002

0.54 [0.38–0.78]

0.001

0.010

0.51 [0.31–0.82]

0.005

0.048

ATA

263 (26.5%)

469 (47.2%)

262 (26.4%)

994 (100%)

rs13301

AERD

22 (15.6%)

65 (46.1%)

54 (38.3%)

141 (100%)

0.64 [0.5–0.82]

4.20 × 10−4

0.004

0.57 [0.39–0.83]

0.003

0.027

0.5 [0.31–0.81]

0.005

0.043

ATA

265 (26.7%)

468 (47.1%)

261 (26.3%)

994 (100%)

 

Haplotype

 

+/+

−/+

−/−

Total

BL1ht1

AERD

16 (11.3%)

57 (40.4%)

68 (48.2%)

141 (100%)

0.78 [0.6–1.03]

0.084

0.672

0.67 [0.47–0.96]

0.028

0.226

0.94 [0.54–1.64]

0.829

1.000

ATA

119 (12.0%)

498 (50.2%)

376 (37.9%)

993 (100%)

BL1ht3

AERD

9 (6.4%)

44 (31.2%)

88 (62.4%)

141 (100%)

0.86 [0.64–1.17]

0.343

1.000

0.79 [0.55–1.14]

0.213

1.000

1.06 [0.51–2.21]

0.873

1.000

ATA

57 (5.7%)

367 (37.0%)

569 (57.3%)

993 (100%)

BL1ht4

AERD

0 (0.0%)

9 (6.4%)

132 (93.6%)

141 (100%)

0.86 [0.42–1.76]

0.688

1.000

0.87 [0.42–1.79]

0.709

1.000

inf

0.999

1.000

ATA

1 (0.1%)

71 (7.2%)

921 (92.7%)

993 (100%)

BL2ht3

AERD

3 (2.1%)

32 (22.7%)

106 (75.2%)

141 (100%)

0.9 [0.62–1.3]

0.565

1.000

0.86 [0.57–1.3]

0.486

1.000

1.12 [0.33–3.85]

0.856

1.000

ATA

19 (1.9%)

253 (25.4%)

723 (72.7%)

995 (100%)

BL2ht4

AERD

0 (0%)

6 (4.3%)

135 (95.7%)

141 (100%)

0.77 [0.33–1.8]

0.541

1.000

0.77 [0.33–1.84]

0.560

1.000

inf

0.999

1.000

ATA

1 (0.1%)

54 (5.4%)

940 (94.5%)

995 (100%)

  1. R rare allele, C common allele, ATA aspirin tolerant asthmatics, AERD aspirin-exacerbated respiratory disease, OR odd ratio, CI confidence interval
  2. *P values were obtained using logistic regression analysis controlling age of onset, smoking status and BMI as covariates
  3. **Corrected P values for multiple comparison using SNPSpD
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BMC Pulmonary Medicine

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