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Table 5 The association of SNPs in ILVBL gene with the risk of AERD and % decline of FEV1 after adjusting rs1468198

From: Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

The risk of AERD

SNP

OR [95% CI]

P*

Pcorr †

  rs13301

1.16 [0.55–2.41]

0.699

1.000

  rs2074261

0.99 [0.47–2.09]

0.975

1.000

  rs7507755

0.78 [0.52–1.17]

0.226

1.000

  rs2240299

0.78 [0.52–1.16]

0.220

1.000

  rs2074265

1.24 [0.94–1.61]

0.123

1.000

  rs718100

1.24 [0.95–1.63]

0.109

1.000

  rs4141356

1.18 [0.91–1.53]

0.222

1.000

  rs2074267

0.96 [0.72–1.28]

0.772

1.000

% decline of FEV1

SNP

β (± SE)

P**

Pcorr †

  rs13301

1.08 ± 1.25

0.387

1.000

  rs2074261

0.06 ± 1.29

0.964

1.000

  rs7507755

−0.64 ± 0.69

0.353

1.000

  rs2240299

−0.65 ± 0.69

0.344

1.000

  rs2074265

0.34 ± 0.51

0.505

1.000

  rs718100

0.31 ± 0.51

0.535

1.000

  rs4141356

0.19 ± 0.49

0.702

1.000

  rs2074267

0.12 ± 0.52

0.814

1.000

  1. *, ** P values were obtained using logistic and linear regression analysis, respectively, controlling age of onset, smoking status, BMI, and genotype of rs1468198as covariates
  2. † Corrected P values for multiple comparison using SNPSpD
  3. OR odd ratio, CI confidence interval, SE standard error