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Table 2 PAH-targeted therapy received prior to switching to riociguat

From: Riociguat in patients with chronic thromboembolic pulmonary hypertension: results from an early access study

Therapy, n (%)

Full analysis set

(n = 300)

Any prior therapy

84 (28)

Endothelin receptor antagonists

44 (15)

 Ambrisentan

8 (3)

 Bosentan

36 (12)

PDE5 inhibitors

58 (19)

 Sildenafil

42 (14)

 Tadalafil

16 (5)

Prostacyclins and prostacyclin analogues

7 (2)

 Beraprost

1 (<1)

 Iloprost

6 (2)

Combination therapy

24 (8)

 Double therapy

23 (8)

 Triple therapy

1 (<1)

  1. PAH pulmonary arterial hypertension, PDE5 phosphodiesterase type 5