From: Adjunctive corticosteroid therapy for inpatients with Mycoplasma pneumoniae pneumonia
Characteristic | No corticosteroid | Low-dose corticosteroids | High-dose corticosteroids | Â | |||
---|---|---|---|---|---|---|---|
n = 1829 | n = 267 | n = 132 | p value | ||||
Patient Characteristics | |||||||
Age, years | 49.2 | ±22.6 | 49.8 | ±21.1 | 53.7 | ±22.3 | 0.0760 |
Male | 847 | (46.3) | 106 | (39.7) | 69 | (52.3) | 0.0405 |
Preexisting comorbid conditions | |||||||
 Charlson comorbidity index | 0.63 | ±1.0 | 1.17 | ±1.2 | 0.88 | ±0.9 | < 0.0001 |
 Congestive heart failure | 108 | (5.9) | 35 | (13.1) | 10 | (7.6) | < 0.0001 |
 Renal disease | 32 | (1.8) | 3 | (1.1) | 2 | (1.5) | 0.7493 |
 Liver disease | 92 | (5.0) | 5 | (1.9) | 6 | (4.5) | 0.0717 |
 Diabetes without chronic complications | 144 | (7.9) | 25 | (9.4) | 17 | (12.9) | 0.1086 |
 Diabetes with chronic complications | 33 | (1.8) | 6 | (2.2) | 1 | (0.8) | 0.5723 |
 Chronic obstructive pulmonary disease | 85 | (4.6) | 22 | (8.2) | 8 | (6.1) | 0.0413 |
 Bronchial asthma | 157 | (8.6) | 110 | (41.2) | 31 | (23.5) | < 0.0001 |
 Interstitial lung disease and fibrosis | 62 | (3.4) | 19 | (7.1) | 34 | (25.8) | < 0.0001 |
 Pleural effusion | 117 | (6.4) | 14 | (5.2) | 11 | (8.3) | 0.4910 |
 Aspiration or drainage of pleural effusion | 4 | (0.2) | 3 | (1.1) | 2 | (1.5) | 0.0108 |
Pneumonia characteristics | |||||||
Parameters of the A-DROP | |||||||
 Age (male ≥ 70 years, female ≥ 75 years) | 473 | (25.9) | 58 | (21.7) | 43 | (32.6) | 0.0642 |
 Dehydration | 201 | (11.0) | 39 | (14.6) | 19 | (14.4) | 0.1344 |
 Confusion | 196 | (10.7) | 63 | (23.6) | 56 | (42.4) | < 0.0001 |
 Respiratory failure | 38 | (2.1) | 12 | (4.5) | 8 | (6.1) | 0.0025 |
 Low blood pressure | 176 | (9.6) | 37 | (13.9) | 17 | (12.9) | 0.0638 |
Pneumonia severity | |||||||
 Mild | 1110 | (60.7) | 137 | (51.3) | 48 | (36.4) | < 0.0001 |
 Moderate | 645 | (35.3) | 111 | (41.6) | 75 | (56.8) |  |
 Severe | 58 | (3.2) | 14 | (5.2) | 6 | (4.5) |  |
 Extremely severe | 16 | (0.9) | 5 | (1.9) | 3 | (2.3) |  |
Other treatments | |||||||
Anti-mycoplasmal drug use | |||||||
 Macroride | 695 | (38.0) | 104 | (39.0) | 49 | (37.1) | 0.9314 |
 Quinolone | 548 | (30.0) | 116 | (43.4) | 69 | (52.3) | < 0.0001 |
 Tetracycline | 569 | (31.1) | 78 | (29.2) | 30 | (22.7) | 0.1172 |
Other supportive drug use | |||||||
 Catecholamine | 13 | (0.7) | 5 | (1.9) | 8 | (6.1) | < 0.0001 |
Interventions | |||||||
 Invasive ventilation | 10 | (0.5) | 5 | (1.9) | 12 | (9.1) | < 0.0001 |
 Non-invasive ventilation | 2 | (0.1) |  | (0.0) | 2 | (1.5) | 0.0009 |
Organization characteristics | |||||||
Intensive care unit admission | 8 | (0.4) | 5 | (1.9) | 10 | (7.6) | < 0.0001 |
Academic hospital | 131 | (7.2) | 16 | (6.0) | 17 | (12.9) | 0.0345 |
Average number of patients in hospital per day | |||||||
 ≤ 200 | 351 | (19.2) | 40 | (15.0) | 26 | (19.7) | 0.2502 |
 201–600 | 1194 | (65.3) | 190 | (71.2) | 81 | (61.4) |  |
 ≥ 601 | 284 | (15.5) | 37 | (13.9) | 25 | (18.9) |  |