Disease progression in idiopathic pulmonary fibrosis with mild physiological impairment: analysis from the Australian IPF registry

Table 2 Univariable Cox analysis

	n	HR	95% CI		p
Age	416	1.03	1.01	1.05	0.013
male	416	1.96	1.25	3.08	0.003
BMI	412	0.94	0.89	0.98	0.003
Smoking	416	1.93	1.20	3.11	0.007
Physiology
FVC (L)	416	0.56	0.43	0.74	<0.001
FVC (%pred)^a	416	0.71	0.64	0.79	<0.001
DLco (%pred)^a	416	0.56	0.49	0.64	<0.001
6MWD^b	164	0.82	0.73	0.92	0.001
SpO2 at rest	163	0.88	0.82	0.95	0.001
SpO2 at end	160	0.92	0.88	0.95	<0.001
SpO2 nadir	153	0.92	0.89	0.96	<0.001
CPI	416	1.09	1.07	1.11	<0.001
GAP stage	416	4.48	3.37	5.95	<0.001
Patient reported outcomes
SGRQ total^c	383	1.11	1.06	1.15	<0.001
UCSD SOBQ^a	243	1.23	1.13	1.33	<0.001
Cough severity^a	347	1.08	0.99	1.17	0.069

BMI body mass index, FVC forced vital capacity, DLco diffusion capacity for carbon monoxide, CPI composite physiological index, GAP gender age physiology, 6MWD 6 min walk distance, SpO2 peripheral blood oxygen saturation, SGRQ St George’s Respiratory Questionniare, UCSD- SOBQ University of California San Diego shortness of breath questionnaire. ^aFor every 10 unit change; ^b for every 50 m change; ^cfor every 4 point change

ISSN: 1471-2466