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Table 2 Univariable Cox analysis

From: Disease progression in idiopathic pulmonary fibrosis with mild physiological impairment: analysis from the Australian IPF registry

  n HR 95% CI p
Age 416 1.03 1.01 1.05 0.013
male 416 1.96 1.25 3.08 0.003
BMI 412 0.94 0.89 0.98 0.003
Smoking 416 1.93 1.20 3.11 0.007
Physiology
 FVC (L) 416 0.56 0.43 0.74 <0.001
 FVC (%pred)a 416 0.71 0.64 0.79 <0.001
 DLco (%pred)a 416 0.56 0.49 0.64 <0.001
 6MWDb 164 0.82 0.73 0.92 0.001
 SpO2 at rest 163 0.88 0.82 0.95 0.001
 SpO2 at end 160 0.92 0.88 0.95 <0.001
 SpO2 nadir 153 0.92 0.89 0.96 <0.001
 CPI 416 1.09 1.07 1.11 <0.001
 GAP stage 416 4.48 3.37 5.95 <0.001
Patient reported outcomes
 SGRQ totalc 383 1.11 1.06 1.15 <0.001
 UCSD SOBQa 243 1.23 1.13 1.33 <0.001
 Cough severitya 347 1.08 0.99 1.17 0.069
  1. BMI body mass index, FVC forced vital capacity, DLco diffusion capacity for carbon monoxide, CPI composite physiological index, GAP gender age physiology, 6MWD 6 min walk distance, SpO2 peripheral blood oxygen saturation, SGRQ St George’s Respiratory Questionniare, UCSD- SOBQ University of California San Diego shortness of breath questionnaire. aFor every 10 unit change; b for every 50 m change; cfor every 4 point change