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Table 5 Parameters of respiratory pump function, exercise capacity and biomarkers

From: Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1

Parameter UED group LED group Mean difference (UED-LED) 95% CI of difference p-value for difference
Number Mean ± SD Median (25%; 75%) Number Mean ± SD Median (25%; 75%) lower upper
PImax %pred 66 102.9 ± 34.0 100.7 (81.5; 123.2) 50 91.9 ± 31.9 90.9 (70.4; 111.0) 11.0 −1.3 23.3 0.079
log10(P01, kPa) 66 −0.72 ± 0.22 − 0.69 (− 0.89; − 0.55) 50 −0,53 ± 0,20 −0.53 (− 0.64; − 0.41) −0.19 − 0.27 −0.11 < 0.001
log10(P01/PImax) 66 −1.57 ± 0.27 −1.52 (− 1.74; − 1.41) 50 −1.34 ± 0.30 −1.34 (− 1.54; − 1.12) − 0.22 − 0.33 − 0.12 < 0.001
6MWD %pred 71 113.0 ± 17.9 114.2 (98.8; 126.1) 51 98.9 ± 21.1 101.4 (91.1; 112.4) 14.1 6.9 21.4 < 0.001
PRE Dyspnoea 60 0.06 ± 0.21 0.00 (0.00; 0.00) 49 0.51 ± 0.92 0.00 (0.00; 1.00) − 0.45 −0.72 − 0.18 0.001
POST Dyspnoea 60 1.63 ± 1.51 1.00 (0.50; 3.00) 49 2.62 ± 1.78 3.00 (1.00; 4.00) −1.00 − 1.63 −0.36 0.002
PRE Fatigue 60 0.26 ± 0.61 0.00 (0.00; 0.00) 49 0.62 ± 0.97 0.00 (0.00; 1.00) −0.36 −0.68 − 0.05 0.025
POST Fatigue 60 0.61 ± 1.20 0.00 (0.00; 0.88) 49 1.09 ± 1.30 0.50 (0.00; 2.00) −0.48 −0.96 − 0.01 0.048
eCO, ppm 72 3.5 ± 1.3 3.0 (3.0; 4.0) 51 4.4 ± 1.2 4.0 (3.0; 5.0) −0.8 −1.3 −0.4 < 0.001
log10(FeNO, ppb) 72 1.305 ± 0.164 1.306 (1.206; 1.422) 51 1.334 ± 0.222 1.317 (1.179; 1.508) −0.029 −0.102 0.044 0.433
serum 8-OHdG, ng/mL 72 0.181 ± 0.065 0.186 (0.129; 0.228) 50 0.178 ± 0.065 0.180 (0.144; 0.212) 0.002 −0.022 0.026 0.845
Telomere length, T/S ratio 72 1.562 ± 0.244 1.564 (1.412; 1.699) 50 1.489 ± 0.179 1.472 (1.344; 1.609) 0.073 −0.003 0.149 0.058
  1. Reference values were calculated according to Enright et al. [16] for PImax and according to Enright and Sherrill [17] for 6MWD
  2. p-values below 0.05 are shown in bold