Table 4 Overview on studies that evaluated different antibiotic protocols for the eradication of MRSA after its first detection
Author | Patients treated | Age of patients (years) | Treatment protocol | Eradication success (%) |
|---|---|---|---|---|
Solis et al. [13] | 12 | median 9.8 (0,6–17) | 5 days topic/inhaled vancomycin | 58 |
Macfarlane et al. [8] | 17 | mean 12.3 (1.8–16.5) | 1. oral rifampicin and fusidic acid over 5 days | 47% |
2. If still positive: oral rifampicin and fusidic acid over additional 5 days | 71% | |||
3. If still positive: intravenous teicoplanin | 94% | |||
Hall et al. [1] | 29 | mean 30 (17–62) | either single or dual oral antibiotic therapy, until negative sputum, minimum 2 weeks, maximum 8 weeks | single therapy 50% dual therapy 85% |
Kappler et al. [17] | 37 | mean 15.3 (0.6–36.9) | 3 weeks dual intravenous + 6 weeks dual oral antibiotics + inhaled vancomycin if still positive 6 weeks inhaled vancomycin | 84 |
Muhlebach et al. Treatment [16] | 22 | mean 12.3 (SD 6.6) | 2 weeks dual oral antibiotics (rifampicin and trimethoprim/sulfamethoxazole or rifampicin an minocycline) | 82 |
Muhlebach et al. Observational control [16] | 19 | mean 10.5 (SD 5.5) | none | 26 |
this study | 7 | Median 15 (4–30) | Oral rifampicin and fusidic acid + inhaled vancomycin over 7 days | 86 |