Fig. 4

HRCT and surgical lung biopsy of 58-year-old never-smoking woman. a Computed tomography scan shows traction bronchiectasis, reticulation, and ground-glass opacity predominantly in the peribronchovascular zone of both lower lungs. b Pathologic specimen (H & E staining, × 40) shows fibrotic nonspecific interstitial pneumonia with emphysematous change (grade 2). c Muscular pulmonary artery shows medial hypertrophy (grade 1) (Elastica van Gieson staining, × 100). d Pulmonary venule lying along the alveolar ducts shows no apparent intimal thickening (Elastica van Gieson staining, × 200). e Venule and interlobular vein show intimal thickening (Elastica van Gieson staining, × 200)