Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patients

Table 1 Burkholderia Eradication Protocol

	Medication	Dosing	Frequency	Route	Bacteria Targeted
Induction Period (21 Days):	Tobramycin	6 mg/kg (per kinetics)	Daily	IV	PsA, Bcc
	Ceftazidime	2 g	Every 8 h	IV	PsA, Bcc
	Trimethoprim/Sulfamethoxazole	800/160 mg	Twice Daily	Oral	Bcc
	Tobramycin inhaled^a	300 mg	Twice Daily	Nebulized	PsA, Bcc
	Azithromycin	250 mg	Daily	Oral	Anti-inflammatory
Consolidation Period (2 months):	Trimethoprim/Sulfamethoxazole	800/160 mg	Twice daily	Oral	Bcc
	Tobramycin inhaled^a	300 mg	Twice daily	Nebulized	PsA, Bcc
	Azithromycin	250 mg	Daily	Oral	Anti-inflammatory

^aAlternative- TIP (tobramycin dry powder for inhalation, 4 caps (28 mg/cap)) every 12 h

ISSN: 1471-2466