| Baseline | 3 month | 6 month | 9 month | 12 month | |
Visit | 1a | 1b | 2 | 3 | 4 | 5 |
 Time | −21 d (±7 d) | Day 1 | 90 d (±14 d)a | 180 d (±14 d)a | 270 d (±14 d)a | 360 d (±14 d)a |
 Informed consent | X |  |  |  |  |  |
 Medical history | X |  |  |  |  |  |
 In−/exclusion criteria | X | X |  |  |  |  |
 Physical examination, vital signs | X | X | X | X | X | X |
 Physical (in)activity history | X |  |  |  |  |  |
 Anthropometry | X | X | X | X | X | X |
 Spirometry | X | X | X | X | X | X |
 Body plethysmography | X | X | X | X | X | X |
 Oral glucose tolerance test |  | X |  |  | X |  |
 Cardiopulmonary exercise testing | X |  |  | X |  | X |
 Pedometry |  | X | (X)b | X | (X)b | X |
 Physical activity questionnaire (7-day recall) | X | X | X | X | X | X |
 Exacerbations, upper respiratory tract infections, antibiotic use, adverse events | X | X | X | X | X | X |
 CFQ-R questionnaire | X |  |  | X |  | X |
 DASS questionnaire | X |  |  | X |  | X |
 EMI 2 questionnaire | X |  |  | X |  | X |
 Diary, 3-months retrospective questionnaire, Interviewc, Patient-initiated contact | X | X | X | X | X | X |
For Intervention group only | ||||||
 Exercise motivation interviewc | X | X | X | X | X | X |
 Web-based diary, paper diary, pedometerd | XXXXXX | |||||
Schedule of measurements for the sub-studies in selected centers | ||||||
 | Baseline | 3 month | 6 month | 9 month | 12 month | |
 Visit | 1a | 1b | 2 | 3 | 4 | 5 |
 Time | −21 d (±7 d) | Day 1 | 90 d (±14 d) | 180 d (±14 d) | 270 d (±14 d) | 360 d (±14 d) |
 Accelerometrye |  | X |  | X |  | X |
 Multiple breath washoute | X | X |  | X |  | X |
 DXAe | X |  |  | X |  | X |
 Scintigraphye | X |  |  | X |  |  |