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Table 2 UIP Cohort Treatment Exposure During Study Period

From: N-acetylcysteine exposure is associated with improved survival in anti-nuclear antibody seropositive patients with usual interstitial pneumonia

Therapy

NAC Exposed (n = 58)

NAC Unexposed (n = 235)

p-value

NAC monotherapy

29 (50)

0 (0)

< 0.001

Immunosuppressant exposurea

15 (25.9)

54 (22.8)

0.64

 Prednisone

15 (25.9)

53 (22.6)

0.59

 Azathioprine

8 (13.8)

9 (3.8)

0.004

 Mycophenolate mofetil

3 (6.0)

3 (2.8)

0.38

Anti-fibrotic exposure

11 (18.9)

29 (12.3)

0.19

 Pirfenidone

10 (17.2)

24 (10.2)

0.13

 Nintedanib

1 (1.8)

6 (2.6)

1

  1. Abbreviations: UIP usual interstitial pneumonia, NAC N-acetylcysteine
  2. aAzathioprine/prednisone or mycophenolate/prednisone