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Table 3 Variables Predicting Survival in UIP Cohort

From: N-acetylcysteine exposure is associated with improved survival in anti-nuclear antibody seropositive patients with usual interstitial pneumonia

  Unadjusted (n = 293) Adjusted (n = 293)
Characteristic HR p-value 95% CI HR p-value 95% CI
ANA (+) a 1.46 0.02 1.07–1.98 1.59 0.007 1.13–2.23
NAC exposure 0.74 0.13 0.50–1.09 0.68 0.05 0.44–1.0
IPAF diagnosis b 1.11 0.52 0.80–1.57 0.99 0.97 0.67–1.48
Immunosuppressant exposure c 1.05 0.77 0.74–1.49 0.94 0.75 0.64–1.38
Anti-fibrotic exposure d 0.28 < 0.001 0.14-0.57 0.35 0.004 0.17–0.72
GAP Score 1.36 < 0.001 1.23–1.51 1.36 < 0.001 1.23–1.51
  1. Abbreviations: IPF idiopathic pulmonary fibrosis, IPAF interstitial pneumonia with autoimmune features, UIP usual interstitial pneumonia, NAC N-acetylcysteine, ANA antinuclear antibody, GAP gender, age, physiology
  2. aANA titer ≥1:320 or nucleolar or centromere staining pattern at any titer
  3. bCompared to IPF diagnosis
  4. cPrednisone, azathioprine or mycophenolate
  5. dPirfenidone or nintedanib