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Table 3 Variables Predicting Survival in UIP Cohort

From: N-acetylcysteine exposure is associated with improved survival in anti-nuclear antibody seropositive patients with usual interstitial pneumonia

 

Unadjusted (n = 293)

Adjusted (n = 293)

Characteristic

HR

p-value

95% CI

HR

p-value

95% CI

ANA (+) a

1.46

0.02

1.07–1.98

1.59

0.007

1.13–2.23

NAC exposure

0.74

0.13

0.50–1.09

0.68

0.05

0.44–1.0

IPAF diagnosis b

1.11

0.52

0.80–1.57

0.99

0.97

0.67–1.48

Immunosuppressant exposure c

1.05

0.77

0.74–1.49

0.94

0.75

0.64–1.38

Anti-fibrotic exposure d

0.28

< 0.001

0.14-0.57

0.35

0.004

0.17–0.72

GAP Score

1.36

< 0.001

1.23–1.51

1.36

< 0.001

1.23–1.51

  1. Abbreviations: IPF idiopathic pulmonary fibrosis, IPAF interstitial pneumonia with autoimmune features, UIP usual interstitial pneumonia, NAC N-acetylcysteine, ANA antinuclear antibody, GAP gender, age, physiology
  2. aANA titer ≥1:320 or nucleolar or centromere staining pattern at any titer
  3. bCompared to IPF diagnosis
  4. cPrednisone, azathioprine or mycophenolate
  5. dPirfenidone or nintedanib