Skip to main content

Table 4 Multivariable-adjusted NAC-associated mortality risk stratified by ANA seropositivitya

From: N-acetylcysteine exposure is associated with improved survival in anti-nuclear antibody seropositive patients with usual interstitial pneumonia

  ANA (+) a (n = 148) ANA (−) (n = 145)
Characteristic n HR p-value 95% CI n HR p-value 95% CI
NAC exposure 33 0.51 0.01 0.30–0.87 25 1.26 0.45 0.69–2.32
IPAF diagnosis b 64 1.23 0.37 0.78–1.95 13 0.37 0.05 0.14–0.99
Immunosuppressant exposure c 35 0.85 0.54 0.50–1.43 34 1.32 0.32 0.77–2.28
Anti-fibrotic exposure d 20 0.67 0.4 0.27–1.70 22 0.16 0.002 0.05–0.51
GAP Score 148 1.41 < 0.001 1.23–1.61 144 1.27 0.005 1.08–1.50
  1. Abbreviations: NAC N-acetylcysteine, ANA anti-nuclear antibody, IPAF interstitial pneumonia with autoimmune features, GAP gender, age, physiology
  2. aANA titer ≥1:320 or nucleolar or centromere staining pattern at any titer
  3. bCompared to IPF diagnosis
  4. cPrednisone, azathioprine or mycophenolate
  5. dPirfenidone or nintedanib