Skip to main content

Table 3 Recipients characteristics with or without Donor Specific Antibody

From: Prevalence of pre-transplant anti-HLA antibodies and their impact on outcomes in lung transplant recipients

 

Donor Specific Antibody

p-value

 

Yes (n = 10)

No (n = 66)

Anti-HLA Ab (%)

  

< 0.001

 PRA ≥ 50%

7 (70.0)

2 (3.0)

 

Anti-HLA Ab (MFI)

  

< 0.001

  < 1000

0 (0)

45 (68.2)

 

 1000 ≤ MFI < 3000

3 (30.0)

9 (13.6)

 

 3000 ≤ MFI < 5000

1 (10.0)

6 (9.1)

 

  ≥ 5000

6 (60.0)

6 (9.1)

 

Age, median (range), yrs

48.5 (17–57)

52.0 (17–75)

0.180

Male, n (%)

5 (50.0)

37 (56.1)

0.745

BMI, median (IQR), kg/m2

18.4 (14.3–20.0)

19.3 (17.5–22.2)

0.161

ABO, n (%)

  

0.708

 A

2 (20.0)

24 (36.4)

 

 B

4 (40.0)

22 (33.3)

 

 AB

1 (10.0)

5 (7.6)

 

 O

3 (30.0)

15 (22.7)

 

Primary diagnosis, n (%)

  

0.321

 COPD/emphysema

2 (20.0)

2 (3.0)

 

 IPF

3 (30.0)

34 (51.5)

 

 IPAH

0 (0)

1 (1.5)

 

 IIP other than IPF*

0 (0)

3 (4.5)

 

 Bronchiectasis/destroyed lung by TB

0 (0)

4 (6.1)

 

 BOS after HSCT

2 (20.0)

9 (13.6)

 

 Interstitial lung disease related with CTD

1 (10.0)

4 (6.1)

 

 LAM

2 (20.0)

7 (10.6)

 

 Others**

0 (0)

2 (3.0)

 

Smoking, n (%)

  

0.733

 Smoker

3 (30.0)

26 (39.4)

 

   ≥ 20 pack-years

3 (30.0)

19 (28.8)

 

   < 20 pack-years

0 (0)

7 (10.6)

 

  Never smoker

7 (70.0)

40 (60.6)

 

Bilateral lung transplantation, n (%)

9 (90.0)

53 (80.3)

0.678

  1. *NSIP and AIP were included
  2. **Others: diffuse panbronchiolitis, langerhans cell histiocytosis
  3. BMI, body mass index; COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis; IPAH, Idiopathic pulmonary arterial hypertension; IIP, Idiopathic interstitial pneumonia; TB, tuberculosis; BOS, Bronchiolitis obliterans syndrome; CTD, connective tissue disease; LAM, Lymphangioleiomyomatosis; NSIP, non-specific interstitial pneumonia; AIP, acute interstitial pneumonia; HSCT, hematopoietic stem cell transplantation