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Table 5 Association of pre-transplant panel reactive antibody with potential BOS

From: Prevalence of pre-transplant anti-HLA antibodies and their impact on outcomes in lung transplant recipients

 

BOS 0 (n = 14)

≥pBOS (n = 6)

p-value

Total

   

cPRA

  

> 0.999

 Not detected or PRA < 50%, n (%)

12 (85.7)

5 (83.3)

 

 PRA ≥ 50%, n (%)

2 (14.3)

1 (16.7)

 

Anti-HLA Ab (MFI)

  

0.131

 Not detected or MFI < 3000, n (%)

12 (85.7)

3 (50)

 

 MFI ≥ 3000, n (%)

2 (14.3)

3 (50)

 

Class I

   

cPRA

  

> 0.999

 Not detected or PRA < 50%, n (%)

12 (85.7)

5 (83.3)

 

 PRA ≥ 50%, n (%)

2 (14.3)

1 (16.7)

 

Class I anti-HLA Ab (MFI)

  

0.549

 Not detected or MFI < 3000, n (%)

12 (85.7)

4 (66.7)

 

 MFI ≥ 3000, n (%)

2 (14.3)

2 (33.3)

 

Class II

   

cPRA

  

–

 Not detected or PRA < 50%, n (%)

14 (100)

6 (100)

 

 PRA ≥ 50%, n (%)

–

–

 

Class II anti-HLA Ab (MFI)

  

0.079

 Not detected or MFI < 3000, n (%)

14 (100)

4 (66.7)

 

 MFI ≥ 3000, n (%)

0 (0)

2 (33.3)

 

Donor Specific Antibody

  

> 0.999

 Yes, n (%)

2 (14.3)

1 (16.7)

 

 No, n (%)

12 (85.7)

5 (83.3)

 

CMV status

   

 Donor + / Recipient -, n (%)

0 (0)

0 (0)

–

 Donor + / Recipient +, n (%)

14 (100)

6 (100)

–

Donor BAL culture +, n (%)

9 (64.3)

2 (33.3)

0.336

Pseudomonas aeruginosa colonization, n (%)

1 (7.1)

1 (16.7)

0.521

Ischemic time, min (mean ± SD)

213.2 ± 62.8

197.0 ± 55.6

0.386

  1. cPRA, calculated panel reactive antibody; PRA, panel reactive antibody; HLA, human leukocyte antigen; MFI, mean fluorescence intensity; BOS, bronchiolitis obliterans syndrome; pBOS, potential bronchiolitis obliterans syndrome; CMV, cytomegalovirus; BAL, bronchoalveolar lavage