Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma

BMC Pulmonary Medicine

Table 4 Linear regression analysis of lung function and ACQ6 by sex hormone levels in males 6–18 years with asthma

Outcome variable	Covariate remaining in the model*	Beta coefficient	Covariate p value	R squared	P value of the model
Pre-BD FEV₁ (%)	Log (DHEA-S)	9.285	0.011	0.168	0.011
Post-BD FEV₁ (%)	Log (DHEA-S)	9.527	0.006	0.160	0.006
Pre-BD FVC (%)	log (DHEA-S)	9.121	0.007	0.157	0.007
ACQ6	Log (DHEA-S)	−0.008	0.019	0.214	0.018
	Testosterone	−0.005	0.031
	log (DHEA-S) *Testosterone #	0.003	0.05

*Results reflect final results of a model that started with testosterone and DHEA-S. Covariates that were not significantly associated with the outcome in this model were then removed by backward selection and model was re-run with remaining variables. # A log (DHEA-S) * testosterone interaction was found and included in the final model

ISSN: 1471-2466