Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

Chandrasekaran, Ravishankar; Mac Aogáin, Micheál; Chalmers, James D.; Elborn, Stuart J.; Chotirmall, Sanjay H.

doi:10.1186/s12890-018-0638-0

BMC Pulmonary Medicine

Table 1 Predominant pathogens identified in bronchiectasis cohort studies

From: Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

Method			Population	Sample size	Predominant pathogens (by sequencing)	Predominant pathogens (by culture)	Ref
Sputum culture	BAL culture	16S rRNA sequencing	Population	Sample size	Predominant pathogens (by sequencing)	Predominant pathogens (by culture)	Ref
✓			Adult	n = 123	N.A.	P. aeruginosa H. influenzae M. avium intracellulare S. pneumoniae S. aureus	[128]
✓			Adult	n = 100	N.A.	P. aeruginosa H. influenzae S. pneumoniae S. aureus M. catarrhalis	[74]
✓			Adult	n = 193	N.A.	H. influenzae P. aeruginosa M. catarrhalis S. pneumoniae S. aureus A. fumigatus	[32]
✓			Adult	n = 155	N.A.	H. influenzae P. aeruginosa S. pneumoniae M. catarrhalis S. aureus	[70]
✓	✓		Adult	n = 77	N.A.	H. influenzae S. pneumoniae P. aeruginosa	[129]
	✓		Children	n = 113	N.A	NTHi S. pneumoniae M. catarrhalis S. aureus P. aeruginosa	[88]
✓			Adult	n = 89	N.A.	H. influenzae P. aeruginosa M. catarrhalis S. pneumoniae S. aureus Aspergillus spp. M.avium complex	[69]
		✓	Adult	n = 11	P. aeruginosa Prevotella spp. Streptococcus spp. Haemophilus spp	N.A.	[65]
		✓	Adult	n = 41	H. influenzae P. aeruginosa S. pneumoniae S. aureus M. catarrhalis	N.A.	[66]
✓		✓	Adult	n = 70	Pseudomonadaceae Pasteurellaceae Streptococcaceae	P. aeruginosa H. influenzae	[71]
✓		✓	Adult	Culture: Stable: n = 40 Exacerbation : n = 11 Sequencing: Stable: n = 10 Exacerbation : n = 19	Haemophilus spp. Pseudomonas spp. Streptococcus spp. Achromobacter spp	Stable patients: P. aeruginosa H. influenzae Prevotella spp. Veillonella spp. Exacerbation patients: P. aeruginosa H. influenzae S. pneumoniae Methicillin-resistant S. aureus	[94]
✓		✓	Adult	Stable n = 76, n = 64/76 patients followed-up during exacerbation.	Hemophilus spp. Pseudomonas spp. Streptococcus spp.	P. aeruginosa S. aureus H. influenzae	[67]

The list order of pathogens corresponds to frequency of identification. Abbreviations: P. aeruginosa – Pseudomonas aeruginosa, NTM – Non-Tuberculosis Mycobacteria, H.influenzae – Haemophilus influenzae, NTHi – Non-typeable Haemophilus influenzae, C. albicans – Candida albicans, S. pneumoniae – Streptococcus pneumoniae, S. aureus – Staphylococcus aureus, M. catarrhalis – Moraxella catarrhalis, A. fumigatus – Aspergillus fumigatus, M. avium – Mycobacterium avium

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ISSN: 1471-2466

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