Higher serum 25-hydroxyvitamin D concentrations are associated with active pulmonary tuberculosis in hospitalised HIV infected patients in a low income tropical setting: a cross sectional study

Table 4 Association of serum 25(OH) D concentrations and outcomes in HIV-infected TB suspects

Variable	Serum 25(OH) D ng/ml Median(IQR)	p-value	Univariate Odds ratio (95%CI)	Multivariate Odds ratio^b (95%CI)
PTB status n = 284				1.84 (1.1–3.2)
1. PTB⁺ n = 145	25.3 (18.0–33.7)	0.0003	1.91 (1.1–3.2)
2. PTB⁻ n = 139	20.4 (14.6–26.9)	0.0003	Referent
8-week outcome n = 265^a				0.90 (0.5–1.7)
1. Alive n = 190	21.91 (16.9–31.1)	0.767	Referent
2. Deceased n = 75	21.97 (15.8–31.7)	0.767	0.93 (0.5–1.7)
Cause of Death n = 75				4.25 (1.1–16.2)
1. PTB n = 49	23.28 (16.6–34.8)	0.059	3.19(0.9–10.7)
2. Other	18.47 (15.0–29.4)	0.059	Referent
Hospital Stay n = 245^a				0.87 (0.5–1.6)
1. ≤7 days n = 179	22.14 (17.0–30.7)	0.740	Referent
2. > 7 days	22.10 (14.5–35.7)	0.740	0.89 (0.5–1.7)

Key: IQR interquartile range, CI confidence interval, PTB pulmonary tuberculosis, TB tuberculosis. p-values of ≤ 0.05 were considered statistically significant. ^asome lost to follow up or incomplete data in records and ^bOR adjusted for binaries of gender, age (≥50 or < 50 years), CD4 cell count (≥200 or < 200 cells/μL) and cART status (experienced or naïve)

ISSN: 1471-2466