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Table 2 Clinical aspects of Non-Invasive Ventilation in Interstitial Lung Diseases

From: Management of acute respiratory failure in interstitial lung diseases: overview and clinical insights

Problem

Tip for solution

High pressures required to obtain ideal tidal volume in fibrotic lung with risk of pneumothorax

- Tolerate low tidal volumes with higher respiratory rate to obtain acceptable minute ventilation

- Low to moderate PEEP levels to avoid overdistension of “healthy” lung units

High respiratory rate that hampers patient-ventilator adaptation

- Titrate drugs to control respiratory rate, e.g. opiates (morphine or fentanyl)§

Intense breathlessness reported by patients especially in the acute phase

- Titrate drugs to control respiratory rate, e.g. opiates (morphine or fentanyl)§

- Rapid inspiratory curve

- Increase FIO2

  1. Footnotes: PEEP = positive end expiratory pressure; FIO2 = fraction of inspired oxygen
  2. § Matsumoto T, Tomii K, Tachikawa R, Otsuka K, Nagata K, Otsuka K, et al. Role of sedation for agitated patients undergoing noninvasive ventilation: clinical practice in a tertiary referral hospital. Bmc Pulm Med. 2015 Jul 13;15:71