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Table 3 Comparison of absolute changes in sputum properties, pulmonary diffusing capacity and oxygen saturation between experiments A and B (N = 15)

From: Acute effects of combined exercise and oscillatory positive expiratory pressure therapy on sputum properties and lung diffusing capacity in cystic fibrosis: a randomized, controlled, crossover trial

 

Experiment A

Experiment B

P-values

Variables

Absolute change pre- versus post-exercise

Absolute change pre- versus 45 min post-exercise

Absolute change pre- versus post-exercise

Absolute change pre- versus 45 min post exercise

Pre- versus post- exercise between A & B

Pre- versus 45 min post- exercise between A & B

Sputum properties

 G’ 1 rad s− 1 (Pa)

1.98 (0.1, 9.9)

− 0.27 (− 3.3, 6.8)

0.87 (− 2.8, 4.8)

3.21 (0.1, 7.2)

0.237

0.290

 G’ 10 rad s− 1 (Pa)

2.54 (1.1, 14.2)

11.35 (−1.0, 16.5)

1.22 (− 3.9, 8.2)

2.90 (− 0.4, 15.1)

0.290

0.725

 G” 1 rad s− 1 (Pa)

0.82 (− 1.2, 3.1)

2.40 (− 0.1, 4.1)

0.46 (− 0.2, 1.63)

1.64 (− 0.2, 3.3)

0.595

0.567

 G” 10 rad s− 1 (Pa)

0.85 (− 0.3, 2.7)

2.52 (− 0.1, 4.0)

0.61 (− 0.6, 1.6)

1.82 (− 0.2, 3.6)

0.468

0.576

 Dynamic yield stress (Pa)

0.07 (0.0, 0.3)

0.20 (0.0, 0.3)

0.01 (−0.1, 0.1)

0.10 (0.0, 0.2)

0.217

0.713

 Sputum solids content (%)

0.25 (−0.1, 3.5)

0.86 (0.4, 1.9)

1.11 (−1.2, 3.4)

0.94 (− 1.6, 3.6)

0.967

0.653

 Spinnability (mm)

1.00 (−0.2, 11.0)

−1.40 (− 14.3, 0.4)

−1.25 (− 3.9, 0.7)

1.20 (− 1.1, 5.7)

0.077

0.009

 Ease of sputum expectoration (cm)

0.50 (− 0.2, 1.7)

0.80 (− 0.1, 1.2)

−0.20 (− 1.6, 1.3)

− 1.1 (− 1.8, 0.1)

0.276

0.016

Pulmonary diffusing capacity

 DLNO (mL min− 1 mmHg− 1)

4.23 (− 0.9, 8.8)

−0.90 (− 2.8, 1.4)

1.40 (− 5.7, 5.1)

−2.86 (− 7.2, 5.0)

0.152

1.000

 DLNO/VA (mL min− 1 mmHg− 1 L− 1)

−0.17 (− 0.6, 0.2)

− 1.04 (− 1.5, − 0.6)

−0.18 (− 0.9, 0.3)

−1.16 (− 1.8, − 0.1)

0.934

0.967

 DLCO (mL min− 1.mmHg− 1)

2.16 (0.8, 4.5)

−0.12 (− 0.8, 0.6)

1.87 (0.1, 2.3)

−0.76 (− 2.1, 0.9)

0.110

0.351

 DLCO/VA (mL min− 1 mmHg− 1 L− 1)

0.28 (0.1, 0.5)

−0.09 (− 0.2, 0.1)

0.21 (0.0, 0.4)

−0.22 (− 0.3, − 0.1)

0.468

0.271

 DLNO/DLCO ratio

− 0.16 (− 0.3, − 0.1)

−0.01 (− 0.2, 0.1)

−0.17 (− 0.4, 0.1)

−0.13 (− 0.2, − 0.0)

0.771

0.533

 DMCO (mL min− 1 mmHg− 1)

1.0 (− 3.0, 3.0)

1.0 (− 5.0, 2.0)

0.0 (− 9.0, 3.0)

2.0 (− 7.0, 5.0)

0.632

0.519

 VA (L)

0.26 (0.0, 0.4)

0.04 (− 0.0, 0.2)

0.06 (− 0.1, 0.3)

0.03 (− 0.2, 0.2)

0.032

0.693

 Vcap (mL)

12.0 (9.0, 17.0)

0.0 (−3.0, 3.0)

12.0 (1.0, 15.0)

−5.0 (− 11.0, 4.0)

0.135

0.114

Oxygen saturation

 SpO2 (%)

0.0 (− 1.5, 1.0)

0.0 (−0.8, 0.5)

0.0 (− 1.0, 0.0)

0.3 (− 0.1, 1.0)

0.983

0.378

  1. Data are displayed as median (interquartile range, IQR). DLCO, diffusing capacity of the lung for carbon monoxide; DLNO, diffusing capacity of the lung for nitric oxide; DMCO, alveolar-capillary membrane diffusing capacity for carbon monoxide; G’, storage modulus; G”, loss modulus; SpO2, oxygen saturation; VA, alveolar volume; Vcap, pulmonary capillary blood volume. Pulmonary gas diffusion variables were measured in SI units (mmol min− 1 kPa− 1) and converted to traditional units (mL min− 1 mmHg− 1) by multiplying with 2.987. Differences in outcome variables at different time points (pre-exercise versus post-exercise and pre-exercise versus 45′ post-exercise) between the two experimental conditions were analyzed using the non-parametric Mann-Whitney-U test
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BMC Pulmonary Medicine

ISSN: 1471-2466

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