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Table 5 Comparison of mean PIF and pressure drop values based on gender

From: Comparison of peak inspiratory flow rate via the Breezhaler®, Ellipta® and HandiHaler® dry powder inhalers in patients with moderate to very severe COPD: a randomized cross-over trial

Gender

 

Breezhaler®

Ellipta®

HandiHaler®

R (cmH2O0.5[L/min]−1)a

0.060

0.090

0.163

Male

n

72

68

72

PIF (L/min)

111 ± 24

81 ± 16

51 ± 9

Range (Min-Max)

54–156

45–109

22–70

Pressure drop at PIF (cmH2O)

47 ± 19

54 ± 20

71 ± 23

ΔPIF vs Breezhaler® (L/min); 95% CI

30; 28 to 34

60; 57 to 65

P-value

< 0.0001

< 0.0001

Female

n

25

23

25

PIF (L/min)

98 ± 15

71 ± 11

45 ± 8

Range (Min-Max)

71–121

49–89

32–57

Pressure drop at PIF (cmH2O)

36 ± 11

41 ± 12

56 ± 20

ΔPIF vs Breezhaler® (L/min); 95% CI

27; 23 to 31

53; 49 to 57

P-value

< 0.0001

< 0.0001

  1. Data are presented as mean ± standard deviation unless stated otherwise. P-values for subgroup analysis are exploratory in nature
  2. CI confidence interval, n number of patients, ΔPIF difference in mean PIF values, PIF peak inspiratory flow rate, R intrinsic airflow resistance of the inhaler
  3. Poor quality (flat-line) inhalational profiles with erroneous PIF values were not considered in the analysis
  4. aData published previously [19, 20]