Table 1 Demographics and Clinical Presentation (N = 41)

Age at diagnosis (mean ± SD)

57 ± 15

Sex

 Male, N (%)

3 (7.3)

 Female, N (%)

38 (92.7)

Positive tobacco use, N (%)

6 (14.6)

Pack year history (median (IQR))

13.5 (6.1-37.5)

Duration of RA prior to diagnosis, years (mean ± SD)

14 ± 12

Use of penicillamine, N (%)

4 (9.8)

Use of gold salts, N (%)

8 (19.5)

Non-pulmonary, extra-articular symptoms at diagnosis, N (%)

10 (24.4)

Active joint symptoms at diagnosis, N (%)

16 (39.0)

Sjögren’s syndrome

7(17)

Respiratory symptoms at diagnosis

 Dyspnea, N (%)

38 (92.7)

 Cough, N (%)

13 (31.7)

 Chest Pain, N (%)

8 (19.5)

Radiologic findings of OB at diagnosis (N=39)

 Mosaic attenuation, N (%)

20 (51.3)

 Centrilobular nodules, N (%)

3 (7.7)

Radiologic findings of other RA-related pulmonary disease (N=39)

 Pulmonary nodules, N (%)

21 (53.8)

 Fibrosis, N (%)

12 (30.8)

 Pleural effusion, N (%)

2 (5.1)

 Bronchiectasis, N (%)

19 (48.7)

Patients biopsied, N (%) (one patient had both wedge and transbronchial)

11 (26.8)

Wedge biopsy, N (%)

5 (41.7)

Transbronchial biopsy, N (%)

7 (58.3)

Unique biopsies consistent with OB diagnosis, N (%)

7 (58.3) (5 wedge, 2 TBB)