Evolution | At inclusion | |||||||
---|---|---|---|---|---|---|---|---|
NO Group | Eosinophil Count Group | Airway Responsiveness FEV1 Group | Airway Responsiveness Resistance Group | |||||
Number of subjects | +a n = 46 | -a n = 272 | +b n = 44 | -b n = 274 | +c n = 44 | -c n = 274 | +d n = 27 | -d n = 291 |
Proportion of subjects with rhinoconjunctivitis-like symptomse | ||||||||
p-value for interaction | p = 0.26 | p = 0.13 | p = 0.57 | p = 0.33 | ||||
Model- predicted value | 29.1% | 29.0% | 32.5% | 28.4% | 25.2% | 29.8% | 23.2% | 29.7% |
OR(p) | 1.01 (0.98) f | 1.4 (0.48) f | 0.70 (0.39) f | 0.59 (0.34) f | ||||
Proportion of subjects with asthma-like symptomse | ||||||||
p-value for interaction | p = 0.50 | p = 0.51 | p = 0.41 | p = 0.32 | ||||
Model- predicted value | 6.5% | 8.6% | 6.3% | 8.7% | 8.8% | 8.4% | 6.3% | 8.7% |
OR(p) | 0.65 (0.56) f | 0.62 (0.50) f | 1.08 (0.90) f | 0.62 (0.55) f | ||||
Percentage decrease during MBC test - FEV1[%]g | ||||||||
p-value for interaction | p = 0.25 | p = 0.11 | p = 0.07 | p = 0.38 | ||||
Model- predicted value | 9.7% | 9.3% | 8.9% | 9.4% | 14.1% | 8.9% | 10.8% | 9.2% |
Difference (p) | 0.44 (0.67) h | 0.47 (0.64) h | 5.43 (0.001) f | 1.63 (0.19) h | ||||
Percentage increase during MBC test - resistance[%]g | ||||||||
p-value for interaction | p = 0.79 | p = 0.84 | p = 0.06 | p = 0.12 | ||||
Model- predicted value | 22.1% | 18.9% | 18.9% | 19.4% | 23.0% | 18.7% | 25.2% | 18.5% |
Difference (p) | 3.28 (0.17) h | −0.58 (0.80) h | 4.24 (0.06) h | 6.8 (0.052) f | ||||
Proportion of subjects with a possible asthmae | ||||||||
p-value for interaction | Not estimable | p = 0.61 | p = 0.59 | p = 0.95 | ||||
Model- predicted value | 0.9% | 1.7% | 2.0% | 1.6% | 5.0% | 1.0% | 3.3% | 1.5% |
OR(p) | 0.50 (0.57) f | 1.30 (0.79) f | 6.19 (0.012) f | 2.53 (0.36) f | ||||
Proportion of subjects with eosinophil count ≥1%e | ||||||||
p-value for interaction | p = 0.94 | p = 0.61 | p = 0.43 | p = 0.50 | ||||
Model- predicted value | 19.2% | 10.1% | 19.6% | 9.3% | 13.4% | 11.5% | 10.5% | 12.0% |
OR(p) | 2.31 (0.003) h | 2.51 (0.001) f | 1.22 (0.497) h | 0.84 (0.66) h | ||||
FeNO level [ppb] g | ||||||||
p-value for interaction | p = 0.31 | p = 0.43 | p = 0.23 | p = 0.33 | ||||
Model- predicted value | 29.7 | 12.9 | 17.7 | 13.9 | 16.7 | 14.0 | 18.7 | 14.0 |
Ratio (p) | 2.30 (< 0.001) f | 1.27 (0.006) h | 1.19 (0.038) h | 1.33 (0.007) h |