From: Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis
Reference | Design | Patients characteristics | Intervention (Number of participants) | Comparator (Number of participants) | Outcomes assessment and definition (Age of outcome assessment) |
---|---|---|---|---|---|
Goldring, 2013 [26] | Single-center non-blinded non-placebo RCT | Pregnant women in London (51°N) (27 weeks gestation, Asian, Middle Eastern, Black and White) without sarcoidosis, osteomalacia, renal dysfunction or tuberculosis | 1. Daily vitamin D (800 IU ergocalciferol until delivery) (n = 60) 2. Bolus vitamin D (a single oral dose of 200,000 IU cholecalciferol (n = 60) | No treatment (n = 60) | 1.Wheeze ever (ISAAC, at age 3) 2. Recurrent wheezing (≥2 episodes of reported wheezing since birth, at age 3) 3. Wheeze in the year prior to assessment (ISAAC, at age 3) 4. Wheeze with a positive asthma predictive index (loose criteria, at age 3) |
Chawes, 2016 [27] | Single-center double-blinded RCT | Pregnant women in Denmark (55°43’N) (≤26 gestational week) without any endocrine, cardiovascular, or nephrological disorders; or vitamin D3 (cholecalciferol) intake more than 600 IU/d | Daily dose of 2400 IU vitamin D3 supplementation (24 gestational week to 1 week postpartum) (n = 315) | Matching placebo tablets (Camette A/S) (24 gestational week to 1 week postpartum) (n = 308) | 1.Persistent wheeze (diagnosed according to a previously validated quantitative algorithm, from birth to age 3 years) 2.Asthma (doctor diagnosed in children fulfilling the persistent wheeze criteria at age 3) |
Litonjua, 2016 [28] | Multicenterdouble-blinded placebo RCT | Pregnant women in Boston (52°58’N), Washington (38°53’N), San Diego (32°43’ N) (age 18–39,10–18 gestational week, nonsmoker, English or Spanish speaking, who or whose partner had a history of allergic disease, with intent to participate for 4 years) | Daily 4000 IU of vitamin D plus a multivitamin with 400 IU of vitamin D (n = 440) | Placebo (daily placebo pill plus a multivitamin with 400 IU of vitamin D) (n = 436) | Asthma or recurrent wheeze in first 3 y of life (parental report, every 3 months) |