From: Agreement in reporting of asthma by parents or offspring – the RHINESSA generation study
Predictor | Univariate analyses Parents | Multivariate analysesa Parents | Univariate analyses Offspring | Multivariate analysesa Offspring | ||||
---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
Male gender | 1.33 (1.11, 1.60) | 0.002 | 1.31 (1.08, 1.59) | 0.007 | 1.01 (0.84, 1.23) | 0.905 | ||
Age | 1.00 (0.99, 1.02) | 0.630 | 1.01 (1.00, 1.02) | 0.058 | ||||
Smoking | ||||||||
Never smoker | 1.00 | 1.00 | 1.00 | |||||
Current smoker | 1.51 (1.11, 2.05) | 0.009 | 1.46 (1.05, 2.02) | 0.023 | 1.14 (0.85, 1.52) | 0.392 | ||
Ex-smoker | 1.28 (1.05, 1.56) | 0.013 | 1.22 (0.99, 1.50) | 0.062 | 1.31 (1.04, 1.64) | 0.021 | 1.22 (0.95, 1.55) | 0.114 |
Education | ||||||||
College/university | 1.00 | 1.00 | ||||||
Primary school | 1.25 (0.94, 1.66) | 0.127 | 1.59 (0.97, 2.59) | 0.065 | ||||
Secondary school | 1.04 (0.86, 1.28) | 0.641 | 1.03 (0.85, 1.26) | 0.756 | ||||
Comorbidity | ||||||||
Hypertension | 0.93 (0.75, 1.15) | 0.505 | 1.42 (0.89, 2.28) | 0.140 | ||||
Stroke | 1.03 (0.52, 2.06) | 0.930 | – | – | ||||
Ischemic heart | 1.88 (1.23, 2.86) | 0.003 | 1.54 (0.96, 2.46) | 0.071 | – | – | ||
Diabetes | 1.64 (1.09, 2.46) | 0.018 | 1.46 (0.96, 2.24) | 0.077 | 1.07 (0.47, 2.48) | 0.868 | ||
COPD | 1.75 (1.07, 2.87) | 0.026 | 1.49 (0.89, 2.50) | 0.129 | – | – | ||
Serious childhood infection < 5 years | 1.12 (0.99, 1.27) | 0.080 | 1.11 (0.98, 1.25) | 0.106 | ||||
Respiratory symptoms | ||||||||
Wheeze | 1.32 (1.07, 1.63) | 0.010 | 1.02 (0.72, 1.46) | 0.902 | 1.58 (1.26, 1.97) | < 0.001 | 1.60 (1.21, 2.11) | 0.001 |
Wheeze with shortness of breath | 1.47 (1.15, 1.89) | 0.002 | 1.22 (0.81, 1.84) | 0.343 | 1.37 (0.92, 2.04) | 0.127 | ||
Awoken with tightness in chest | 1.01 (0.76, 1.36) | 0.924 | 1.16 (0.87, 1.53) | 0.313 | ||||
Awoken with attack of breathlessness | 1.26 (0.89, 1.80) | 0.193 | 1.11 (0.72, 1.72) | 0.634 | ||||
Awoken with attack of cough | 1.28 (1.05, 1.55) | 0.013 | 1.25 (1.00, 1.57) | 0.046 | 0.94 (0.76, 1.16) | 0.557 | ||
Currently taking asthma medication | 1.32 (1.00, 1.76) | 0.058 | 1.42 (1.06, 1.91) | 0.020 | 0.95 (0.60, 1.49) | 0.823 | ||
Age of onset | ||||||||
Early onset | – | – | 1.12 (0.78, 1.62) | 0.528 | ||||
Late onset | – | – | 1.76 (1.32, 2.34) | < 0.001 | 1.45 (1.01, 2.07) | 0.042 |