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Table 3 Odds ratios for discrepant answers in offspring/parent asthma reports, univariate and multivariate logistic regression analysis

From: Agreement in reporting of asthma by parents or offspring – the RHINESSA generation study

Predictor Univariate analyses Parents Multivariate analysesa Parents Univariate analyses Offspring Multivariate analysesa Offspring
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Male gender 1.33 (1.11, 1.60) 0.002 1.31 (1.08, 1.59) 0.007 1.01 (0.84, 1.23) 0.905   
Age 1.00 (0.99, 1.02) 0.630    1.01 (1.00, 1.02) 0.058   
Smoking
 Never smoker 1.00   1.00   1.00    
 Current smoker 1.51 (1.11, 2.05) 0.009 1.46 (1.05, 2.02) 0.023 1.14 (0.85, 1.52) 0.392   
 Ex-smoker 1.28 (1.05, 1.56) 0.013 1.22 (0.99, 1.50) 0.062 1.31 (1.04, 1.64) 0.021 1.22 (0.95, 1.55) 0.114
Education
 College/university 1.00     1.00    
 Primary school 1.25 (0.94, 1.66) 0.127    1.59 (0.97, 2.59) 0.065   
 Secondary school 1.04 (0.86, 1.28) 0.641    1.03 (0.85, 1.26) 0.756   
Comorbidity
 Hypertension 0.93 (0.75, 1.15) 0.505    1.42 (0.89, 2.28) 0.140   
 Stroke 1.03 (0.52, 2.06) 0.930     
 Ischemic heart 1.88 (1.23, 2.86) 0.003 1.54 (0.96, 2.46) 0.071   
 Diabetes 1.64 (1.09, 2.46) 0.018 1.46 (0.96, 2.24) 0.077 1.07 (0.47, 2.48) 0.868   
 COPD 1.75 (1.07, 2.87) 0.026 1.49 (0.89, 2.50) 0.129   
 Serious childhood infection < 5 years 1.12 (0.99, 1.27) 0.080    1.11 (0.98, 1.25) 0.106   
Respiratory symptoms
 Wheeze 1.32 (1.07, 1.63) 0.010 1.02 (0.72, 1.46) 0.902 1.58 (1.26, 1.97) < 0.001 1.60 (1.21, 2.11) 0.001
 Wheeze with shortness of breath 1.47 (1.15, 1.89) 0.002 1.22 (0.81, 1.84) 0.343 1.37 (0.92, 2.04) 0.127   
 Awoken with tightness in chest 1.01 (0.76, 1.36) 0.924    1.16 (0.87, 1.53) 0.313   
 Awoken with attack of breathlessness 1.26 (0.89, 1.80) 0.193    1.11 (0.72, 1.72) 0.634   
 Awoken with attack of cough 1.28 (1.05, 1.55) 0.013 1.25 (1.00, 1.57) 0.046 0.94 (0.76, 1.16) 0.557   
 Currently taking asthma medication 1.32 (1.00, 1.76) 0.058    1.42 (1.06, 1.91) 0.020 0.95 (0.60, 1.49) 0.823
Age of onset
 Early onset    1.12 (0.78, 1.62) 0.528   
 Late onset    1.76 (1.32, 2.34) < 0.001 1.45 (1.01, 2.07) 0.042
  1. aAdjusted for all predictors that were significant in the univariate analyses as well as for study centre and sibling status