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Table 2 Therapy status at follow-up

From: Anti-IL-5 therapy in patients with severe eosinophilic asthma – clinical efficacy and possible criteria for treatment response

Characteristic

All (n = 42)

Anti-IL-5 therapy responder (n = 32)

Anti-IL-5 therapy non-responder (n = 10)

p-value

Anti-IL-5 therapy in month, median (IQR)

12

(7–15)

12

(8–15)

9

(6–12)

0.146

Anti-IL-5 therapy response criteria, n (%)

 lung function (FEV1)

26

(62)

26

(81)

0

(0)

 

 eosinophils

39

(93)

31

(97)

8

(80)

 

 subjective condition

32

(76)

32

(100)

0

(0)

 

OCS therapy after anti-IL-5 therapy initiation

 Continuous OCS therapy at baseline – mg/d, median (IQR)

5

(5–10)

5

(5–10)

5

(5–12.5)

0.821

 Continuous OCS therapy at follow-up, mg/d, median (IQR)

5

(4–12.5)

4.5

(3.3–5)

10

(5–17.5)

0.080

 OCS therapy discontinued at follow-up, n (%)

10

(24)

9

(28)

1

(10)

0.240

  1. OCS oral corticosteroids, FEV1 forced expiratory volume in one second. For comparisons, Fisher’s exact test, Chi-squared test, Mann–Whitney U test or two-sided paired t-test were used as appropriate